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US 2019/0336450 A1Published application
Osmotic drug delivery system
AssigneeSupernus Pharmaceuticals, Inc.
InventorsArgaw Kidane, Padmanabh P. Bhatt
Life of this patent
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Abstract
An oral osmotic pharmaceutical delivery system comprises a highly water-soluble drug exhibiting an erratic or an incomplete release profile when formulated in an elementary osmotic pump delivery system and at least one release enhancing agent.
Claims10
-18. (canceled)
A method of treating pulmonary hypertension in a human subject comprising administering to the human subject a solid oral dosage form comprising:
- (a) an osmotically-active drug core comprising treprostinil or a pharmaceutically acceptable salt thereof;
- and (b) a semi-permeable membrane surrounding the osmotically-active drug core, wherein the semi-permeable membrane comprises at least one opening having a diameter from 100 μm to 800 μm to permit osmotic release of the treprostinil or its pharmaceutically acceptable salt from the osmotically-active drug core, wherein the administration provides a therapeutically effective plasma concentration of treprostinil in the human subject.
Dependencies are inferred from the claim text.