Immunogenic Composition Against Campylobacter Jejuni
AssigneeThe United States of America as represented by the Secretary of the Navy
InventorsPatricia Guerry, Mario Artur Monterio
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Abstract
The inventive subject matter relates to an immunogenic composition against Campylobacter jejuni comprising isolated capsule polysaccharide from selected pathogenic Campylobacter jejuni strains. The inventive subject matter also relates to methods of using the polysaccharide compositions in inducing an anti-C. jejuni immune response.
Claims18
A polysaccharide antigen against Campylobacter jejuni, said polysaccharide antigen comprising an isolated Campylobacter jejuni capsule polysaccharide from a Campylobacter jejuni strain linked to form a repeating polysaccharide polymer comprising 2 or more of said capsule polysaccharides, wherein said Campylobacter jejuni strain is selected from the group consisting of:
- HS4, HS5, HS4/13/64, and HS50, wherein said polysaccharide antigens do not contain Campylobacter jejuni lipooligosaccharide structures associated with Guillain Barré Syndrome, wherein the structure of HS4 is →3)-L-β-D-ido-Hep-(1→4)-β-D -GlcNAc-(1→, with non-stoichiometric MeOPN at C-4 of LD-ido-Hep, wherein the structure of HS4/13/64 is [→3)-6d-β-D-ido-Hep-(1-43 4)-β-D-GlcNAc-(1→]n, with non-stoichiometric MeOPN at C-2 and/or C-7 of 6d-ido-Hep, wherein “n” is 1 to 100, and wherein the structure of HS5 is selected from the group consisting of
A method of immunizing against C. jejuni strains HS4, HS13, HS4/13/64 and HS50 by administering one or more antigens, wherein each of said one or more antigens comprises an isolated polysaccharide or polysaccharide polymers derived from a C. jejuni strain selected from the group consisting of HS4, HS13, HS4/13/64 and HS50;
- wherein the structure of HS4 is →)-L-β-D-ido-Hep-(1→4)-β-D-GlcNAc-(1→, with non-stoichiometric MeOPN at C-4 of LD-ido-Hep;
- wherein the structure of HS4/13/64 is [→3)-6d-β-D-ido-Hep-(1→4)-β-D-GlcNAc -(1→]n, with non-stoichiometric MeOPN at C-2 and/or C-7 of 6d-ido-Hep;
- and wherein “n” is 1 to 100.
Dependencies are inferred from the claim text.