Prebiotic Oral Care Methods Using a Saccharide
AssigneesColgate-Palmolive Company, Katholieke Universiteit Leuven, Universiteit Gent
InventorsHansruedi STETTLER, Wim TEUGHELS, Marc QUIRYNEN, Nico BOON
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Abstract
The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from D-turanose, D-melezitose, D-lactitol, myo-inositol, and N-acetyl-D-mannosamine; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.
Claims29
An oral care composition comprising an effective amount of at least one saccharide prebiotic for use in selectively promoting, in an oral cavity:
- growth, metabolic activity or colonization of bacteria that have beneficial effects on oral health, relative to growth, metabolic activity or colonization of pathogenic oral bacteria.
An oral care composition comprising an effective amount of at least one saccharide prebiotic for use in selectively promoting, in an oral cavity, biofilm formation by bacteria that have beneficial effects on oral health, relative to biofilm formation by pathogenic oral bacteria.
An oral care composition comprising an effective amount of at least one saccharide prebiotic for use in maintaining and/or re-establishing a healthy oral microbiota.
An oral care composition comprising an effective amount of at least one saccharide prebiotic for use in preventing or mitigating one or more of gingivitis, periodontitis, peri-implantitis, peri-implant mucositis, necrotizing gingivitis, necrotizing periodontitis and caries in a subject in need thereof, by selectively promoting in the oral cavity of the subject the growth, metabolic activity or colonization of bacteria that have beneficial effects on oral health, relative to growth, metabolic activity or colonization of pathogenic oral bacteria.
A method for selectively promoting, in an oral cavity:
- growth, metabolic activity or colonization of bacteria that have beneficial effects on oral health, relative to growth, metabolic activity or colonization of pathogenic oral bacteria, comprising administering to the oral cavity an oral care composition comprising an effective amount of at least one saccharide prebiotic.
A method for selectively promoting, in an oral cavity, biofilm formation by bacteria that have beneficial effects on oral health, relative to biofilm formation by pathogenic oral bacteria, comprising administering to the oral cavity an oral care composition comprising an effective amount of at least one saccharide prebiotic.
A method for preventing or mitigating one or more of gingivitis, periodontitis, peri-implantitis, peri-implant mucositis, necrotizing gingivitis, necrotizing periodontitis and caries in a subject in need thereof, by selectively promoting in the oral cavity of the subject the growth, metabolic activity or colonization of bacteria that have beneficial effects on oral health, relative to growth, metabolic activity or colonization of pathogenic oral bacteria, comprising administering to the oral cavity an oral care composition comprising an effective amount of at least one saccharide prebiotic.
A method for screening for compounds that promote the growth of beneficial oral bacteria, wherein screening steps include:
- (i) determining the ability of a first compound to promote the growth of beneficial oral bacteria, while simultaneously negatively affects the growth of pathogenic oral bacteria, and (ii) selecting a test compound for further testing based upon its ability to promote the growth of beneficial oral bacteria and inhibit the growth of pathogenic oral bacteria.
Dependencies are inferred from the claim text.