Novel protein transduction domain and use thereof
AssigneeBioceltran Co., Ltd.
InventorsSang Ho JANG, Gil Whoan LEE, Jung Soon HWANG, Jun Ho PARK, Ju Hee PARK
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Abstract
The present invention relates to a novel protein transduction domain (PTD), which is a peptide having an amino acid sequence represented by SEQ ID NO: 1, and a use thereof. When the peptide represented by SEQ ID NO: 1 of the present invention is used as a PTD, biological molecules (target materials) such as proteins, peptides, DNA and the like can be easily introduced into cells in a high yield.
Claims17
A peptide having an amino acid sequence represented by SEQ ID NO:
- 1.
A conjugate formed by bonding a substance that can be chemically bonded to a peptide having an amino acid sequence represented by SEQ ID NO:
- 1, to the amino acid sequence represented by SEQ ID NO:
- 1.
A complex formed by mixing a substance that can be bonded via hydrophobic interaction or electrostatic attraction to a peptide having an amino acid sequence represented by SEQ ID NO:
- 1, with the amino acid sequence represented by SEQ ID NO:
- 1.
A cosmetic composition comprising:
- a conjugate formed by bonding a substance that can be chemically bonded to a peptide having an amino acid sequence represented by SEQ ID NO:
- 1, to the amino acid sequence represented by SEQ ID NO:
- 1;
- or
- a complex formed by mixing a substance that can be bonded via hydrophobic interaction or electrostatic attraction to a peptide having an amino acid sequence represented by SEQ ID NO:
- 1, with the amino acid sequence represented by SEQ ID NO:
- 1.
A pharmaceutical composition comprising:
- a conjugate formed by bonding a substance that can be chemically bonded to a peptide having an amino acid sequence represented by SEQ ID NO:
- 1, to the amino acid sequence represented by SEQ ID NO:
- 1;
- or
- a complex formed by mixing a substance that can be bonded via hydrophobic interaction or electrostatic attraction to a peptide having an amino acid sequence represented by SEQ ID NO:
- 1, with the amino acid sequence represented by SEQ ID NO:
- 1.
A method for introducing, into cells in a mammal, a substance that can be chemically bonded to a peptide having an amino acid sequence represented by SEQ ID NO:
- 1, comprising bonding the peptide having an amino acid sequence represented by SEQ ID NO:
- 1 to the substance that can be chemically bonded to the peptide having an amino acid sequence represented by SEQ ID NO:
- 1, to introduce, into the cells, the substance that can be chemically bonded to the peptide having an amino acid sequence represented by SEQ ID NO:
- 1.
A method for introducing, into cells in a mammal, a substance that can be bonded via hydrophobic interaction or electrostatic attraction to a peptide having an amino acid sequence represented by SEQ ID NO:
- 1, comprising bonding the peptide having an amino acid sequence represented by SEQ ID NO:
- 1 to the substance that can be bonded via hydrophobic interaction or electrostatic attraction to the peptide having an amino acid sequence represented by SEQ ID NO:
- 1, to introduce, into the cells, the substance that can be bonded via hydrophobic interaction or electrostatic attraction to the peptide having an amino acid sequence represented by SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.