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US 2019/0336198 A1Published application
Systems, devices, and methods for ablation using surgical clamps
OwnerRaju VISWANATHAN, Gary L. LONGinventors
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Abstract
Systems, devices, and methods for electroporation ablation therapy are disclosed, with the device including a first jaw including a plurality of first electrodes and a second jaw including a plurality of second electrodes. The first jaw and the second jaw may be substantially rigid, elongate, and collectively define a longitudinal axis. The first jaw and the second jaw may be configured to engage tissue therebetween during use.
Claims35
An apparatus, comprising:
- a first jaw including a first plurality of electrodes;
- a second jaw including a second plurality of electrodes, the first jaw and the second jaw being substantially rigid, elongate, and collectively defining a longitudinal axis, the first jaw and the second jaw further configured to engage tissue therebetween during use,
- each electrode of the first plurality of electrodes having, within a cross-section of the apparatus that is orthogonal to the longitudinal axis, a width that is less than a length of that electrode, the first plurality of electrodes spaced apart laterally with respect to the longitudinal axis,
- each electrode of the second plurality of electrodes, within the cross-section, having a width that is less than a length of that electrode, the second plurality of electrodes spaced apart laterally with respect to the longitudinal axis;
- and
- a processor operatively coupled to the first plurality of electrodes and the second plurality of electrodes, the processor configured to configure a first electrode of the first plurality of electrodes as an anode and a second electrode of the second plurality of electrodes as a cathode, the first electrode disposed diagonally across from the second electrode within the cross-section and spaced apart laterally with respect to the longitudinal axis from the second electrode,
- the processor configured to deliver the pulse waveform to the first and second electrodes such that the first and second electrodes deliver ablative energy to the tissue to generate irreversible electroporation in the tissue that forms a contiguous ablation zone extending diagonally from the first electrode to the second electrode.
4 more elements
3-4. (canceled)
11-19. (canceled)
22-26. (canceled)
An apparatus, comprising:
- a first jaw including a first electrode and a second electrode;
- a second jaw including a third electrode and a fourth electrode, the first jaw and the second jaw being substantially rigid, elongate, and collectively defining a longitudinal axis, the first jaw and the second jaw further configured to engage tissue therebetween during use, wherein, within a cross-section of the apparatus that is orthogonal to the longitudinal axis, the first electrode is disposed diagonally across from the fourth electrode is spaced apart laterally from the fourth electrode;
- and
- a processor operably coupled to the first jaw and the second jaw, the processor configured to, during use:
- configure the first electrode as an anode and the fourth electrode as a cathode;
- and
- deliver a pulse waveform to the first electrode and the fourth electrode such that the first electrode and the fourth electrode generate a pulsed electric field that delivers ablative energy to the tissue to generate irreversible electroporation in the tissue that forms a contiguous ablation zone with greater width closer to a surface of the tissue adjacent to the first and second electrodes than at a central portion of the tissue.
4 more elements
37-41. (canceled)
44-48. (canceled)
A method of ablating tissue via irreversible electroporation comprising:
- clamping the tissue between a first jaw and a second jaw of an apparatus, the first jaw including a first plurality of electrodes, the second jaw including a second plurality of electrodes, the first jaw and the second jaw being substantially rigid, elongate, and collectively defining a longitudinal axis,
- each electrode of the first plurality of electrodes having a width orthogonal to the longitudinal axis that is less than a length parallel to the longitudinal axis of that electrode, the first plurality of electrodes spaced apart laterally with respect to the longitudinal axis,
- each electrode of the second plurality of electrodes having a width orthogonal to the longitudinal axis that is less than a length parallel to the longitudinal axis of that electrode, the plurality of second electrodes spaced apart laterally with respect to the longitudinal axis;
- configuring a first electrode of the first plurality of electrodes as an anode;
- configuring a second electrode of the second plurality of electrodes as a cathode, the first and second electrodes, within a cross-section of the apparatus that is orthogonal to the longitudinal axis, being disposed diagonally across from one another and being spaced apart laterally from one another;
- generating, using a pulse generator, a pulse waveform having an amplitude of at least 200 Volts;
- delivering the pulse waveform to the first and second electrodes such that the first and second electrodes generate a pulsed electric field that causes irreversible electroporation in the tissue and generates an ablation zone that forms non-centrally in the tissue.
4 more elements
(canceled)
The method of 49, wherein clamping the tissue comprises transitioning the first and second jaws between a first configuration for advancing the apparatus and a second configuration for clamping the tissue.
The method of 49, further comprising:
- receiving signal data corresponding to electrical activity of the tissue using one or more electrodes of the first plurality of electrodes and of the second plurality of electrodes;
- and
- generating electrocardiography data using the signal data.
The method of 49, further comprising positioning the first and second jaws through or around a body cavity, organ system, or anatomical structure.
56-58. (canceled)
Dependencies are inferred from the claim text.