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US 2019/0336052 A1Published application
Optical glucometer
AssigneeFurman University
InventorsWILLIAM M BAKER, M. PAIGE OUZTS
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Abstract
Disclosed herein are devices and methods for detecting blood glucose levels in a subject that involve passively quantifying mid-infrared emissions from the eye of the subject.
Claims46
An apparatus for detecting blood glucose levels in a subject, comprising:
- a thermographic imaging device configured to capture mid-infrared (MIR) electromagnetic emissions;
- and
- a computing device communicatively connected to the thermographic imaging device, wherein the computing device comprises a processor and memory operably connected to the processor, wherein the memory has computer-executable instructions stored thereon that, when executed by the processor, cause the processor to:
- receive a plurality of images of the subject's eye captured by the thermographic imaging device;
- using the plurality images of the subject's eye, calculate an average radiance value for a pixel region of interest;
- correct the average radiance value for the pixel region of interest based on a temperature of the subject's eye at the time of image capture;
- and
- correlate the corrected average radiance value for the pixel region of interest to a blood glucose value of the subject.
5 more elements
A method for detecting blood glucose levels in a subject, comprising:
- capturing, using a thermographic imaging device, a plurality of images of the subject's eye;
- calculating, using a computing device, an average radiance value for a pixel region of interest based on the plurality images of the subject's eye;
- correcting, using the computing device, the average radiance value for the pixel region of interest based on a temperature of the subject's eye at the time of image capture;
- and
- correlating, using the computing device, the corrected average radiance value for the pixel region of interest to a blood glucose value of the subject.
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A blood-glucose detection apparatus comprising:
- a mid-infrared (MIR) electromagnetic emissions sensor having a field of view,
- a frame configured to align the sensor in front of a subject's eye,
- a collimating ring limiting the field of view to a defined region about the center of the eye, wherein the collimating ring defines the distance from the detector to the subject's eye,
- a processor and computerized memory configured to measure blood glucose concentration in the subject by initiating computer implemented instructions to:
- store a set of standard control values comprising average control radiance values, for a selected wavenumber, induced at the pixels for MIR emitted through respective transmission media having known glucose concentrations, wherein the control values are accessible by the processor,
- receive, in a measurement cycle utilizing the selected wavenumber, a radiance measurement corresponding to MIR incident upon each of the respective pixels;
- calculate an average radiance measurement from the respective radiance measurements corresponding to respective measurement cycles in a plurality of measurement cycles;
- correlate the average radiance measurement to the known glucose concentration having a control radiance value equal to the average radiance measurement.
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An optical glucometer comprising:
- an infrared camera comprising an array of pixels connected to a processor that correlates blood glucose values to radiance measurements induced by mid-infrared radiation (MIR) incident upon the respective pixels;
- and
- computer memory connected to the processor, the computer memory storing a set of standard control values comprising average control radiance values, for a selected wavenumber, induced at the pixels for MIR emitted through respective transmission media having known glucose concentrations, wherein the control values are accessible by the processor, and
- the processor is configured to:
- receive, in a measurement cycle utilizing the selected wavenumber, a radiance measurement corresponding to MIR incident upon each of the respective pixels;
- calculate an average radiance measurement from the respective radiance measurements corresponding to respective measurement cycles in a plurality of measurement cycles;
- correlate the average radiance measurement to the known glucose concentration having a control radiance value equal to the average radiance measurement.
4 more elements
A method of measuring blood glucose concentration in eye, comprising:
- storing a set of standard control values, wherein the set of standard control values comprises average control radiance values, for a selected wavenumber, induced at pixels of a mid-infrared radiation (MIR) sensor for MIR emitted through respective transmission media having known glucose concentrations;
- storing, during a measurement cycle, radiance measurements corresponding to mid-infrared radiation (MIR) emitted from the eye and incident upon the pixels;
- calculating an average radiance measurement from the respective radiance measurements corresponding to respective measurement cycles in a plurality of measurement cycles;
- and
- correlating the average radiance measurement to the known blood glucose concentration having an average control radiance value equal to the average radiance measurement.
2 more elements
Dependencies are inferred from the claim text.