Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

An electrochemical continuous glucose sensor configured for implantation in a host, the glucose sensor comprising:

• an electrode configured to measure a signal indicative of a glucose concentration of a host, wherein the signal comprises a glucose-related component and a non-glucose related component;
• and
• a membrane covering at least a portion of the electrode, wherein the membrane is configured to reduce passage of an interfering species therethrough, whereby the non-glucose-related component of the signal is less than about 20% of the signal over a period of at least one day;
• wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.