Methods and arrangements for obtaining information and providing analysis for biological tissues
AssigneeThe General Hospital Corporation
InventorsSeok-Hyun Yun, Giuliano Scarcelli
Life of this patent
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Abstract
Arrangements and methods can be provided for determining information associated with at least one section of at least one biological tissue. For example, it is possible to provide at least one first electro-magnetic radiation to the section(s) of the biological tissue(s) in vivo so as to interact with at least one acoustic wave in the biological tissue(s). At least one second electro-magnetic radiation can be produced based on the interaction. At least one portion of the at least one second electro-magnetic radiation can be received, and the information associated with the section(s) of the biological tissue(s) can be determined based on the portion of the second electromagnetic radiation(s).
Claims21
A system for rapid spectroscopic analysis of an ocular tissue comprising:
- a radiation source configured to provide a first electromagnetic radiation to the ocular tissue, wherein the first electromagnetic radiation is configured to interact with an acoustic wave in the ocular tissue to produce a second electromagnetic radiation that is different from the first electromagnetic radiation;
- an imaging system including a spectrometer comprising:
- a first stage positioned to receive at least a portion of the second electromagnetic radiation,
- a second stage positioned to receive at least a portion of the second electromagnetic radiation from the first stage,
- an aperture mask positioned in close proximity to a focal plane between the first and second stages and configured to block at least a portion of an intensity profile of the second electromagnetic radiation, the blocked portion including a subset of spectral components of a resolved spectral pattern,
- a first filter positioned between the first stage and the aperture mask and configured to change a shape of the intensity profile of the second electromagnetic radiation as a function of spatial distance transverse to a propagation direction of the second electromagnetic radiation;
- and
- wherein the spectrometer is configured to collect light for acquiring a spectrum of the second electromagnetic radiation using a light collection duration short enough to acquire the spectrum in less than 1 second.
A method for rapid spectroscopic analysis of an ocular tissue comprising:
- providing a first electromagnetic radiation to an ocular tissue to interact with an acoustic wave in the ocular tissue, wherein a second electromagnetic radiation different from the first electromagnetic radiation is produced based on the interaction;
- receiving the second electromagnetic radiation;
- determining a spectrum of the second electromagnetic radiation using a spectrometer that comprises:
- a first stage positioned to receive at least a portion of the second electromagnetic radiation,
- a second stage positioned to receive at least a portion of the second electromagnetic radiation from the first stage,
- an aperture mask positioned in close proximity to a focal plane between the first and second stages and configured to block at least a portion of an intensity profile of the second electromagnetic radiation, the blocked portion including a subset of spectral components of a resolved spectral pattern,
- a first filter positioned between the first stage and the aperture mask and configured to change a shape of the intensity profile of the second electromagnetic radiation as a function of spatial distance transverse to a propagation direction of the second electromagnetic radiation;
- and
- wherein the spectrometer is configured to collect light for acquiring the spectrum of the second electromagnetic radiation using a light collection duration short enough to acquire the spectrum in less than 1 second.
Dependencies are inferred from the claim text.