Compositions for organ preservation
AssigneeSigmaDrugs Kutató Korlátolt Felelösségü Társaság
InventorsAndrea FEKETE, Ádám VANNAY, Ádám HOSSZÚ
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Abstract
The invention relates to the field of preserving the viability of organs or tissues to be transplanted into a recipient in need of such a transplantation. In particular, the invention relates to use of a sigma 1 receptor agonist compound in preservation solutions and preservation solutions comprising a sigma 1 receptor agonist compound.
Claims24
1-37. (canceled)
A method for reducing or delaying cellular damage that occurs during ex vivo storage of a transplantable whole or partial organ or tissue, the method comprising
- (i) contacting the whole or partial organ or tissue ex vivo with a composition comprising an amount of a sigma 1 receptor (S1R) agonist compound effective in reducing or delaying cellular damage of said transplantable whole or partial organ or tissue during ex vivo storage and a physiologically acceptable solution suitable for ex vivo organ preservation,
- (ii) maintaining the transplantable whole or partial organ or tissue ex vivo in said composition before transplantation.
A composition for reducing or delaying cellular damage that occurs during ex vivo storage of a transplantable whole or partial organ or tissue, the composition comprising (a) an amount of a sigma 1 receptor (S1R) agonist compound effective in reducing or delaying cellular damage of said transplantable whole or partial organ or tissue during ex vivo storage and (b) a physiologically acceptable solution suitable for ex vivo organ preservation.
Dependencies are inferred from the claim text.