Genetically modified non-human animal with human or chimeric cd28
AssigneeBiocytogen Pharmaceuticals (Beijing) Co., Ltd.
InventorsYuelei Shen, Yang Bai, Yanan Guo, Meiling Zhang, Rui Huang, Chengzhang Shang, Jiawei Yao
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Abstract
The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD28, and methods of use thereof.
Claims28
A genetically-modified, non-human animal whose genome comprises at least one chromosome comprising a sequence encoding a human or chimeric CD28.
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A genetically-modified, non-human animal, wherein the genome of the animal comprises a replacement of a sequence encoding a region of endogenous CD28 with a sequence encoding a corresponding region of human CD28 at an endogenous CD28 gene locus.
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A method for making a genetically-modified, non-human animal, comprising:
- replacing in at least one cell of the animal, at an endogenous CD28 gene locus, a sequence encoding a region of an endogenous CD28 with a sequence encoding a corresponding region of human CD28.
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Dependencies are inferred from the claim text.