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US 2019/0335725 A1Published application
Genetically sterile animals
AssigneeRecombinetics, Inc.
InventorsScott C. Fahrenkrug, Daniel F. Carlson
Life of this patent
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Abstract
A genetically modified livestock animal, and methods of making and using the same, the animal comprising a genetic modification to disrupt a target gene selectively involved in gametogenesis, wherein the disruption of the target gene prevents formation of functional gametes of the animal. Animals that create progeny with donor genetics, and methods of making and using the same. Cells, and methods of making and using the cells, with a genetic modification to disrupt a target gene selectively involved in gametogenesis.
Claims22
-30. (canceled)
A method for producing livestock animals via surrogacy comprising:
- i) editing a gene responsible for gametogenesis in a primary cell to produce an edited primary cell containing a knockout of the gene responsible for gametogenesis;
- ii) cloning the edited primary cell to produce an infertile host animal;
- iii) implanting gametes from a donor animal into the infertile host animal;
- wherein the infertile host animal produces functional sperm or ova derived from the donor animal;
- iv) breeding the host animal with another animal to produce progeny of the donor animal.
2 more elements
Dependencies are inferred from the claim text.