Phosphonamidates that are Bcl Family Antagonists for Use in Clinical Management of Conditions Caused or Mediated By Senescent Cells and for Treating Cancer

A compound of formula (I):

• wherein:
• X1 is O or S;
• R1 is selected from SR21, OR21, and NR21R22;
• R3 is selected from hydrogen, alkyl and substituted alkyl;
• R4 is selected from hydrogen, alkyl, substituted alkyl, nitro, alkylsulfonyl, substituted alkylsulfonyl, alkylsulfinyl, substituted alkylsulfinyl, cyano, alkylcarbonyl, substituted alkylcarbonyl, C(O)OH, C(O)NH2, halogen, SO2NH2, alkylaminosulfonyl, substituted alkylaminosulfonyl, alkylsulfonylamino and substituted alkylsulfonylamino, alkanoyl, substituted alkanoyl, alkylaminocarbonyl, substituted alkylaminocarbonyl, alkyloxycarbonyl and substituted alkyloxycarbonyl;
• R21 and R22 are independently selected from hydrogen, alkyl and substituted alkyl;
• or R21 and R22 together with the N atom through which they are connected form a 5 to or 6-membered heterocyclic ring, optionally substituted with one or more R23;
• Z2 is selected from —NR5R6, hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkoxy, substituted alkoxy, alkylsulfanyl, substituted alkylsulfanyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, carbocycle, substituted carbocycle, heterocycle, substituted heterocycle, arylalkoxy, substituted arylalkoxy, aryloxy, substituted aryloxy, aryloxyalkoxy, substituted aryloxyalkoxy, arylsulfanyl, substituted arylsulfanyl, arylsulfanylalkoxy, substituted arylsulfanylalkoxy, cycloalkylalkoxy, substituted cycloalkylalkoxy, cycloalkyloxy, substituted cycloalkyloxy, halogen, carbonyloxy, haloalkoxy, haloalkyl, hydroxy and nitro;
• Z3 is selected from heterocycle, substituted heterocycle, —NR5R6, aryl, substituted aryl, heteroaryl, substituted heteroaryl, carbocycle and substituted carbocycle;
• R5 and R6 are independently selected from hydrogen, alkyl and substituted alkyl;
• R11 and R12 are each one or more optional substituents each independently selected from alkyl, substituted alkyl, alkoxy, substituted alkoxy, halogen, cyano, nitro, carboxy, C(O)NH2, SO2NH2, sulfonate, hydroxyl, alkylsulfonyl, substituted alkylsulfonyl, alkylaminosulfonyl, substituted alkylaminosulfonyl, alkylsulfonylamino, substituted alkylsulfonylamino, alkyloxycarbonyl, substituted alkyloxycarbonyl and —NR5R6;
• and
• R31 is selected from H, R12 and L3-Y3 wherein L3 is a linker and Y3 is selected from aryl, substituted aryl, heteroaryl and substituted heteroaryl.