Pharmaceutical formulation
AssigneeF2G Limited
InventorsDerek LAW, Graham Edward Morris SIBLEY
Life of this patent
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Abstract
A pharmaceutical composition suitable for oral administration comprising particles of 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide is provided. Also provided is a pharmaceutical composition suitable for parenteral administration wherein the composition comprises 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide. The compositions are useful in the treatment of fungal infection in a subject in need thereof.
Claims29
A pharmaceutical composition suitable for oral administration wherein the composition comprises spray-dried particles of a compound of Formula I or a pharmaceutically acceptable salt thereof
- 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide
A pharmaceutical composition according to any one of the preceding claims which further comprises one or more excipients.
A pharmaceutical composition according to any one of the previous claims wherein the particles are obtainable by spray-drying from a solution comprising an organic solvent selected from dichloromethane, methanol, and mixtures thereof.
A pharmaceutical composition according to any one of the previous claims and further comprising one or more pharmaceutically acceptable binders and/or carriers and/or excipients and/or diluents and/or adjuvants.
A pharmaceutical composition according to any one of the previous claims in the form of a solid oral dosage form.
A pharmaceutical composition according to any one of the previous claims in the form of a liquid oral dosage form.
A pharmaceutical composition suitable for parenteral administration comprising (i) a compound of Formula I or a pharmaceutically acceptable salt thereof,
- 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide
- (ii) cyclodextrin or modified cyclodextrin, and (iii) polyethylene glycol.
A pharmaceutical composition according to any one of the previous claims for use in a method of treatment of a human or animal subject in need thereof.
A method of producing a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof
- 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide
- wherein said method comprises spray-drying a solution of the compound of Formula (I) or salt thereof.
A pharmaceutical composition suitable for oral administration wherein the composition comprises substantially amorphous particles of a compound of Formula I or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.