Compositions and methods for inhibiting biolfilm deposition and production
AssigneeThe Trustees of the University of Pennsylvania
InventorsKoo HYUN, Henry DANIELL
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Abstract
The invention provides a method for combating biofilm, said method comprising contacting a biofilm with a composition comprising an effective amount of antimicrobial peptide biofilm enzyme combinations, preferably in the form of a fusion protein. The biofilm may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides a composition for use in the treatment or prevention of a biofilm in a subject, particularly in the oral cavity.
Claims25
A multi-component composition comprising at least one antimicrobial peptide (AMP) and at least one biofilm degrading enzyme which act synergistically to degrade biofilm structures and inhibit biofilm deposition, said composition biologically acceptable carrier for delivery of said composition.
Dependencies are inferred from the claim text.