Composition for anti-rna-virus comprising eprs protein or fragment thereof
AssigneesKorea Research Institute of Bioscience and Biotechnology, Medicinal Bioconvergence Research Center
InventorsMyung Hee Kim, Eun Young Lee, Sung Hoon Kim, Chul Ho Lee
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Abstract
The present invention relates to an EPRS (glutamyl-prolyl-tRNA synthetase) protein or a fragment thereof. The EPRS protein of the present invention or fragment thereof may bind to PCBP2 protein to activate the MAVS signaling pathway, and thus it has anti-RNA viral effects, thereby being effective for preventing or treating a RNA viral infectious disease.
Claims20
A method of preventing or treating a RNA viral infectious disease, comprising administering to a subject an EPRS (glutamyl-prolyl-tRNA synthetase) protein, a fragment thereof, or a composition of an EPRS protein or a fragment thereof, wherein the fragment of the EPRS protein comprises an amino acid sequence at positions 168 to 186 in SEQ ID NO:
- 63.
A method of preventing or inhibiting MAVS protein degradation comprising administering to a subject an EPRS (glutamyl-proplyl-tRNA synthetase) protein, a fragment thereof, or a composition comprising an EPRS protein or a fragment thereof, wherein the fragment of the EPRS protein comprises an amino acid sequence at positions 168 to 186 of SEQ ID NO:
- 63.
An EPRS protein or a fragment thereof, wherein the fragment of the EPRS protein comprises an amino acid sequence at positions 168 to 186 of SEQ ID NO:
- 63.
Dependencies are inferred from the claim text.