# US 2019/0316205 A1 · Mmp1 gene transcript for use as a marker for diagnosis of ovarian cancer prognosis, and test method

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- Number: US 2019/0316205 A1
- Document ID: US20190316205A1
- Status: Published application
- Kind: A1
- Application number: 16/312,093
- Filed: 2017-06-20
- Published: 2019-10-17
- Earliest claimed: 2016-06-20
- Assignees: National Cancer Center; BIOMIMETICS SYMPATHIES. Inc
- Applicants: National Cancer Center; Biomimetics Sympathies, Inc.
- Inventors: Takahiro Ochiya; Akira Yokoi; Tomoyasu Kato
- Web page: https://patentgrep.com/patent/US20190316205A1

## CPC

- C12Q 1/6886: for cancer (immunoassay for cancer G01N33/575)
- C12Q 1/6851: Quantitative amplification
- C12Q 1/6853: using modified primers or templates
- C12N 15/09: Recombinant DNA-technology
- C12Q 2600/118: Prognosis of disease development
- C12Q 2600/158: Expression markers
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)

## Abstract

[Problem] To provide: a marker and a kit both for use in the prediction of ovarian cancer prognosis; and a prognosis prediction method. [Solution] A marker and a kit, both for use in the prediction of ovarian cancer prognosis, each of said marker and kit containing a transcript of matrix metalloprotease (MMP) 1 gene; and a method for predicting ovarian cancer prognosis using the marker or the kit, in which the expression level of matrix metalloprotease (MMP) 1 gene in a biological sample collected from a subject is by detecting an ovarian cancer prognosis prediction marker comprising a transcript of matrix metalloprotease (MMP) 1 gene and then obtaining a detection value of the ovarian cancer prognosis prediction marker.

## Claims

### Claim at position 1

1, A method for predicting the prognosis of ovarian cancer, comprising obtaining a detection value of a transcription product of full-length matrix metalloprotease (MMP) 1 gene in ascites collected from a subject or exosomes recovered from ascites, and measuring the expression level of the full-length matrix metalloprotease (MMP) 1 gene.

### Claim at position 2 (depends on 1)

2, The method of claim 1, further comprising the step of comparing the detection value of the transcription product of the full-length matrix metalloprotease (MMP) 1 gene with a detection value of a transcription product of the internal standard gene in the ascites collected from the subject or the exosomes recovered from the ascites, and determining that the detection value of the transcription product of the full-length matrix metalloprotease (MMP) 1 gene is positive when the ratio of the detection value of the transcription product of the full-length matrix metalloprotease (MMP) 1 gene to the detection value of the transcription product of the internal standard gene in the ascites or the exosomes recovered from the ascites is a predetermined ratio or more.