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US 2019/0315669 A1Published application
Process for the preparation of hu-910 and crystalline structure thereof
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsJean-Michel ADAM, Pascal DOTT, Marcus HOHLER, Tanja BURGER, Orazio TAGLIENTE, Ernst MISCHLER
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Abstract
The invention provides processes for the preparation of HU-910, which are scalable to industrial purposes, using safer reagents and having high yield and pure product and a crystalline structure of HU-910, which is a unique product thereof.
Claims10
-23. (canceled)
A process for the preparation of HU-910 including the steps of:
- (a) Preparation of resorcinol building block comprising:
- (b) Preparing the triflate ketopinic methyl ester derivative building block comprising:
- (c) Coupling the resorcinol building block and the triflate ketopinic methyl ester derivative building block comprising to produce a coupled compound:
- (d) Forming compound HU-910 from said coupled compound:
1 more element
A crystalline structure of ((1S,4R)-2-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-7,7-dimethylbicyclo[2.2.1]hept-2-en- 1-yl)methanol (HU-910) having the following unit cell:
- a=33.098(7) A alpha=90 deg., b=7.1740(14) A beta=124.70(3) deg. and c=25.105(5) A gamma=90 deg.
Dependencies are inferred from the claim text.