# US 2019/0314548 A1 · Extracellular Matrix Implant > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2019/0314548 A1 - Document ID: US20190314548A1 - Status: Published application - Kind: A1 - Application number: 16/343,253 - Filed: 2017-11-19 - Published: 2019-10-17 - Earliest claimed: 2016-11-22 - Assignees: Keramed, Inc. - Inventors: Yichieh Shiuey - Web page: https://patentgrep.com/patent/US20190314548A1 ## CPC - A61F 2/142: {Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue} - A61L 27/227: {Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24} - A61K 31/525: Isoalloxazines, e.g. riboflavins, vitamin B2 - A61K 38/39: Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG] - A61L 27/20: Polysaccharides - A61L 27/24: Collagen - A61L 27/3633: {Extracellular matrix [ECM]} - A61L 2300/204: with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines - A61L 2300/216: with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups - A61L 2300/30: Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera - A61L 2300/80: characterised by a special chemical form - A61L 2430/16: for reconstruction of eye parts, e.g. intraocular lens, cornea - A61L 2430/40: Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract A corneal implant includes one or more extracellular matrix (ECM) components; and one or more crosslinking/polymerization promoting agents, wherein the one or more ECM components undergo crosslinking/polymerization on exposure to an initiator. ## Claims ### Claim 1 An implant, comprising: one or more extracellular matrix (ECM) components; and one or more crosslinking/polymerization promoting agents, wherein the one or more ECM components undergo crosslinking/polymerization on exposure to an initiator. ### Claim 2 (depends on 1) The implant of claim 1, wherein the implant is a corneal implant. ### Claim 3 (depends on 1) The implant of claim 1, wherein the ECM components and the one or more crosslinking/polymerization promoting agents is in a liquid or gel form. ### Claim 4 (depends on 1) The implant of claim 1, wherein the one or more extracellular matrix (ECM) components undergo crosslinking/polymerization with the one or more crosslinking/polymerization promoting agents on exposure to an initiator. ### Claim 5 (depends on 1) The implant of claim 1, wherein the one or more ECM components is an ECM protein or a ECM carbohydrate, or a combination thereof. ### Claim 6 (depends on 5) The implant of claim 5, wherein the one or more ECM components is collagen, heparan sulfate, chondroitin sulfate, keratan sulfate, hyaluronic acid, elastin, fibronectin, laminin, or a combination thereof. ### Claim 7 (depends on 1) The implant of claim 1, wherein the one or more crosslinking/polymerization promoting agents is a photoreactive agent, a carbohydrate, or a plant extract. ### Claim 8 (depends on 7) The implant of claim 7, wherein the photoreactive agent is riboflavin or rose bengal and the initiator is ultraviolet light. ### Claim 9 (depends on 4) The implant of claim 4, wherein the one or more crosslinking/polymerization promoting agents is an aldehyde, an isocyanate, or a carbodiimide. ### Claim 10 (depends on 9) The implant of claim 9, wherein the one or more crosslinking/polymerization promoting agents is glutaraldehyde, hexamethylene diisocyanate, or 1-ethyl-3-(3-dimethylamino-propyl) carbodiimide. ### Claim 11 (depends on 1) The implant of claim 1, wherein the initiator is electromagnetic radiation including ultraviolet light, infrared light, and visible light, or the initiator is ultrasound, magnetism, or heat. ### Claim 12 (depends on 1) The implant of claim 1, wherein the implant strengthens or reshapes a body tissue that contains one or more extracellular matrix (ECM) proteins. ### Claim 13 A method of preparing a corneal implant, comprising: mixing one or more extracellular matrix (ECM) components with one or more crosslinking/polymerization promoting agents; and inserting the mixture into an eye of a patient in need thereof, wherein the ECM proteins undergo crosslinking with the one or more crosslinking/polymerization promoting chemical agents on exposure to an initiator. ### Claim 14 (depends on 13) The method of preparing a corneal implant of claim 13, wherein the ECM components and the one or more crosslinking/polymerization promoting agents is in a liquid or gel form. ### Claim 15 (depends on 13) The method of preparing a corneal implant of claim 13, wherein the one or more extracellular matrix (ECM) components undergo crosslinking/polymerization with the one or more crosslinking/polymerization promoting agents on exposure to an initiator. ### Claim 16 (depends on 13) The method of preparing a corneal implant of claim 13, wherein the one or more ECM components is an ECM protein or a ECM carbohydrate, or a combination thereof. ### Claim 17 (depends on 16) The method of preparing a corneal implant of claim 16, wherein the one or more ECM components is collagen, heparan sulfate, chondroitin sulfate, keratan sulfate, hyaluronic acid, elastin, fibronectin, laminin, or a combination thereof. ### Claim 18 (depends on 13) The method of preparing a corneal implant of claim 13, wherein the one or more crosslinking/polymerization promoting agents is a photoreactive agent, a carbohydrate, or a plant extract. ### Claim 19 (depends on 18) The method of preparing a corneal implant of claim 18, wherein the photoreactive agent is riboflavin or rose bengal and the initiator is ultraviolet light. ### Claim 20 (depends on 13) The method of preparing a corneal implant of claim 13, wherein the one or more crosslinking/polymerization promoting agents is an aldehyde, an isocyanate, or a carbodiimide. ### Claim 21 (depends on 20) The method of preparing a corneal implant of claim 20, wherein the one or more crosslinking/polymerization promoting agents is glutaraldehyde, hexamethylene diisocyanate, or 1-ethyl-3-(3-dimethylamino-propyl) carbodiimide. ### Claim 22 (depends on 13) The method of preparing a conical implant of claim 13, wherein the initiator is electromagnetic radiation including ultraviolet light, infrared light, and visible light, or the initiator is ultrasound, magnetism, or heat. ### Claim 23 (depends on 13) The method of preparing a corneal implant of claim 13, wherein the implant strengthens or reshapes a body tissue that contains one or more extracellular matrix (ECM) proteins.