# US 2019/0314441 A1 · Method For The Management Of Cancer And Cancer Treatment-Related Comorbidities

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- Number: US 2019/0314441 A1
- Document ID: US20190314441A1
- Status: Published application
- Kind: A1
- Application number: 16/453,379
- Filed: 2019-06-26
- Published: 2019-10-17
- Earliest claimed: 2013-11-08
- Assignees: Legacy Healthcare Ltd.
- Applicants: Legacy Healthcare Ltd.
- Inventors: Saad HARTI; JiaWei LIU
- Web page: https://patentgrep.com/patent/US20190314441A1

## CPC

- A61K 36/88: Liliopsida (monocotyledons)
- A61K 31/352: condensed with carbocyclic rings, e.g. methantheline {(cannabinoids A61K31/658)}
- A61K 36/5777: {Theobroma, e.g. cocao or cocoa}
- A61K 36/752: Citrus, e.g. lime, orange or lemon
- A61K 36/77: Sapindaceae (Soapberry family), e.g. lychee or soapberry
- A61K 36/8962: Allium, e.g. garden onion, leek, garlic or chives
- A61P 1/08: for nausea, cinetosis or vertigo; Antiemetics
- A61P 3/02: Nutrients, e.g. vitamins, minerals
- A61P 7/06: Antianaemics
- A61P 17/00: Drugs for dermatological disorders
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 25/24: Antidepressants
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method for the management of cancer and treatment of cancer comorbidities, including but not limited to cancer-related fatigue, cachexia, anorexia, pain, anemia, asthenia, depression, muscle weakness, nausea, vomiting, skin, and skin appendages adverse reactions; the method including the administration by the conventional and non-conventional oral, topical, parenteral routes and intra-tumoral injection, or in combination thereof, or the administration as adjuvant potentiator in other therapies using the forenamed routes, of a composition containing as active ingredient an extract of Allium species, which contains querceting, an extract of Citrus species and an extract of Pauffinia species and an extract of Theobroma species.

## Claims

### Claim 1

A method for managing cancer and for treating at least one cancer comorbidity selected from the group consisting of cachexia, anorexia, pain, anemia, asthenia, depression, muscle weakness, nausea, vomiting, adverse skin reactions, adverse skin appendages reactions, and a combination thereof in a subject in need thereof, the method comprising:
administering to the subject, by an oral route, a topical route, a parenteral route, an intra-tumoral injection, or a combination thereof, a composition comprising as active ingredients an extract of Allium species comprising quercetin, an extract of Citrus species, an extract of Pauffinia species, and an extract of Theobroma species.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the composition contains the extract of the Allium species comprising quercetin, the extract of the Citrus species, an atomized extract of the Pauffinia species and an atomized extract of the Theobroma species.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the composition comprises:
from 30% to 93% by weight of the extract of the Allium species comprising quercetin,
from 3% to 33% by weight of the extract of the Citrus species,
from 0.10% to 2.5% by weight of the atomized extract of the Paullinia species, and
from 0.10% to 2.5% by weight of the atomized extract of the Theobroma species,
wherein the percentages are based on the total weight of the four active ingredients.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the at least one cancer comorbidity comprises pain, depression, muscle weakness, adverse skin reactions, adverse skin appendages reactions, or a combination thereof.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the extract of Allium species is an extract of Allium cepa.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the extract of Citrus species is an extract of Citrus lemon.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the extract of Pauffinia species is an extract of Pauffinia cupana.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the extract of Theobroma species is an extract of Theobroma cacao.

### Claim 9 (depends on 1)

The method according to claim 1, wherein the composition comprises:
approximately 87% by weight of an extract of Allium cepa comprising quercetin;
approximately 12% by weight of an extract of Citrus lemon;
approximately 0.5% by weight of an extract of Pauffinia cupana; and
approximately 0.5% by weight of an extract of Theobroma cacao,
wherein the percentages are based on the total weight of the four active ingredients.

### Claim 10

A method for managing cancer and for treating at least one cancer comorbidity in a subject in need thereof, the method comprising:
administering to the subject a composition comprising an extract of Allium species, an extract of Citrus species, an extract of Pauffinia species, and an extract of Theobroma species.

### Claim 11 (depends on 10)

The method according to claim 10, wherein the extract of Allium species comprises quercetin.

### Claim 12 (depends on 10)

The method according to claim 10, wherein the administering is performed orally, topically, or parenterally.

### Claim 13 (depends on 10)

The method according to claim 10, wherein at least one of the extract of Pauffinia species or the extract of Theobroma species is atomized.

### Claim 14 (depends on 10)

The method according to claim 10, wherein the composition comprises:
from 30% to 93% by weight of the extract of the Allium species;
from 3% to 33% by weight of the extract of the Citrus species;
from 0.10% to 2.5% by weight of the extract of the Pauffinia species; and
from 0.10% to 2.5% by weight of the extract of the Theobroma species,
wherein the percentages are based on the total weight of the extract of Allium cepa, the extract of Citrus lemon, the extract of Pauffinia cupana, and the extract of Theobroma cacao.

### Claim 15 (depends on 10)

The method according to claim 10, wherein the composition consists of the extract of Allium species, the extract of Citrus species, the extract of Pauffinia species, and the extract of Theobroma species.

### Claim 16 (depends on 10)

The method according to claim 10, wherein the at least one cancer comorbidity is cancer-related fatigue, cachexia, anorexia, pain, anemia, asthenia, depression, muscle weakness, nausea, vomiting, adverse skin reactions, adverse skin appendages reactions, or a combination thereof.

### Claim 17

A method for managing cancer and for treating at least one cancer comorbidity in a subject in need thereof, the method comprising:
administering to the subject a composition comprising:
from 30% to 93% by weight of an extract of Allium cepa comprising quercetin;
from 3% to 33% by weight of an extract of Citrus lemon;
from 0.10% to 2.5% by weight of an extract of Pauffinia cupana; and
from 0.10% to 2.5% by weight of an extract of Theobroma cacao,
wherein the percentages are based on the total weight of the extract of Allium cepa, the extract of Citrus lemon, the extract of Pauffinia cupana, and the extract of Theobroma cacao.

### Claim 18 (depends on 17)

The method according to claim 17, wherein the composition comprises:
approximately 87% by weight of the extract of Allium cepa comprising quercetin;
approximately 12% by weight of the extract of Citrus lemon;
approximately 0.5% by weight of the extract of Pauffinia cupana; and
approximately 0.5% by weight of the extract of Theobroma cacao.

### Claim 19 (depends on 17)

The method according to claim 17, wherein the composition consists of the extract of Allium cepa comprising quercetin, the extract of Citrus lemon, the extract of Pauffinia cupana; and the extract of Theobroma cacao.

### Claim 20 (depends on 17)

The method according to claim 17, wherein the administering comprises administering the composition to the subject daily for at least 6 months.