# US 2019/0314280 A1 · Aerosol liposome of marine extract and method of producing the same

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- Number: US 2019/0314280 A1
- Document ID: US20190314280A1
- Status: Published application
- Kind: A1
- Application number: 16/423,668
- Filed: 2019-05-28
- Published: 2019-10-17
- Earliest claimed: 2016-04-20
- Assignees: Fisheries Research Institute, Council of Agriculture
- Applicants: Fisheries Research Institute, Council of Agriculture
- Inventors: YI-FENG KAO; YI-CHEN CHEN; CHWEN-HERNG WU
- Web page: https://patentgrep.com/patent/US20190314280A1

## CPC

- A61K 9/127: Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K 9/0073: {Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy; (nasal sprays A61K9/0043; inhalation of vapours of volatile or heated drugs, e.g. essential oils or nicotine, A61K9/007; devices A61M)}
- A61K 9/12: Aerosols; Foams {(A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015)}
- A61K 31/685: one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
- A61K 35/60: Fish, e.g. seahorses; Fish eggs
- A61K 35/618: Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

An aerosol liposome of a marine extract and a method of producing the same are introduced. The marine extract is extracted from cell membranes of marine processing streams, including phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), and lysophosphatidylcholine (LysoPC), further including at least phosphatidylserine (PS). The aerosol liposome is of a particle diameter of less than 2,000 nm. The surface of the aerosol liposome carries phosphatidylserine (PS) molecules. The aerosol liposome of a marine extract is simple and stable and can be absorbed through the mouth, nose, upper respiratory tract, and epidermis and engulfed by macrophages therein to quickly alleviate or regulate systematic inflammatory responses and prevent inflammation-related diseases.

## Claims

### Claim 1

A method of producing an aerosol liposome, for producing an marine extract aerosol liposome, comprising the step of atomizing the marine extract into the aerosol liposome with an aerosol atomizer, wherein the marine extract is extracted from cell membranes of marine processing streams, comprises phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), and lysophosphatidylcholine (LysoPC), includes at least phosphatidylserine (PS), and is characterized in that the aerosol liposome is of a particle diameter of less than 10,000 nm, and a surface of the aerosol liposome carries phosphatidylserine (PS) molecules.

### Claim 2 (depends on 1)

The method of claim 1, wherein marine extract-derived solids, a marine extract-containing solvent, and a marine extract suspension are added to an aqueous solution to get diluted and atomized with an aerosol atomizer to synthesize the aerosol liposomes.

### Claim 3 (depends on 2)

The method of claim 2, wherein a member selected from the group consisting of the nucleic acid matter, cytokine, and valent ion is added to an aqueous solution.