# US 2019/0314263 A1 · Composition comprising a crosslinked hyaluronic acid (ha) in combination with a low-molecular ha and/or an agent stimulating endogenous ha synthesis > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2019/0314263 A1 - Document ID: US20190314263A1 - Status: Published application - Kind: A1 - Application number: 16/453,813 - Filed: 2019-06-26 - Published: 2019-10-17 - Earliest claimed: 2016-12-29 - Assignees: Galderma Holding SA - Applicants: Nestlé Skin Health SA - Inventors: Claire MALLARD; Yves RIVAL - Web page: https://patentgrep.com/patent/US20190314263A1 ## CPC - A61K 8/735: {Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof} - A61K 8/14: Liposomes; Vesicles - A61K 8/35: Ketones, e.g. benzophenone - A61K 8/9789: Magnoliopsida [dicotyledons] - A61Q 19/08: Anti-ageing preparations - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract A composition comprising, in a physiologically acceptable medium, a crosslinked hyaluronic acid (HA), having a degree of modification less than 1.9 mole %; a HA with a molecular weight of about 50 kDa or less; and/or an agent stimulating endogenous HA synthesis. Also disclosed is a cosmetic use of such composition in skin care and/or anti-ageing treatment. ## Claims ### Claim 1 A composition comprising, in a physiologically acceptable medium: (a) a crosslinked hyaluronic acid, wherein the degree of modification of the crosslinked hyaluronic acid is less than 1.9 mole %; and (b) an non-crosslinked hyaluronic acid with a molecular weight of about 50 kDa or less, an agent stimulating endogenous hyaluronic acid synthesis, or a combination thereof. ### Claim 2 (depends on 1) The composition of claim 1, further comprising an anti-aging active ingredient. ### Claim 3 (depends on 2) The composition of claim 2, wherein the anti-aging active ingredient is an anti-aging plant extract. ### Claim 4 (depends on 2) The composition of claim 2, wherein the anti-aging plant extract is selected from the group consisting of Malus domestica plant stem cells, Glycerin (and) Globularia cordifolia Callus culture extract, edelweiss stem cells, and Plantago lanceolata leaf extract. ### Claim 5 (depends on 2) The composition of claim 2, wherein the anti-aging active ingredient is Plantago lanceolata leaf extract. ### Claim 6 (depends on 1) The composition of claim 1, wherein the degree of modification of the crosslinked hyaluronic acid is between 0.1 and 1.9 mole %. ### Claim 7 (depends on 1) The composition of claim 1, wherein the degree of modification the crosslinked hyaluronic acid is about 1.0 mole %. ### Claim 8 (depends on 1) The composition according to claim 1, wherein the crosslinked hyaluronic acid is sodium hyaluronate crosspolymer-2. ### Claim 9 (depends on 1) The composition of claim 1, wherein the non-crosslinked hyaluronic acid has a molecular weight between 20 kDa and 50 kDa. ### Claim 10 (depends on 1) The composition of claim 1, wherein the agent stimulating endogenous hyaluronic acid synthesis is selected from the group consisting of retinoids, retinyl derivatives, alpha-hydroxy acids, Transforming Growth Factor beta, plant extracts, and natural ingredients. ### Claim 11 (depends on 1) The composition according to claim 1, wherein the agent stimulating endogenous hyaluronic acid synthesis is 6-paradol. ### Claim 12 (depends on 1) The composition according to claim 1, wherein the crosslinked hyaluronic acid is loaded onto, loaded into, or loaded onto and into, micro- or nanoparticular vesicles. ### Claim 13 (depends on 12) The composition according to claim 12, wherein the crosslinked hyaluronic acid is loaded onto the vesicle and/or into the vesicle at a concentration between 0.01% and 5% (w/w). ### Claim 14 (depends on 12) The composition according to claim 12, wherein the crosslinked hyaluronic acid is loaded onto the vesicle and/or into the vesicle at a concentration of 0.175%, 0.35%, or 0.5%. ### Claim 15 (depends on 12) The composition according to claim 12, wherein the micro- or nanoparticular multilamellar vesicles comprise concentric membranes comprising at least one non-ionic surfactant of the sucrose ester type comprising at least one chain arising from a linear or branched, saturated or unsaturated, optionally mono- or polyhydroxylated, C12 to C22 fatty acid. ### Claim 16 (depends on 15) The composition of claim 15, wherein: the crosslinked hyaluronic acid is crosslinked with 1,4-butanediol diglycidyl ether and has a degree of modification of about 1.0 mole %; the non-crosslinked hyaluronic acid has a molecular weight of between 20 kDa and 50 kDa; the agent stimulating endogenous hyaluronic acid synthesis is 6-paradol; and the anti-aging active agent is Plantago lanceolata leaf extract. ### Claim 17 (depends on 16) The composition of claim 16 comprising, relative to the total weight of the composition: (a) 0.1 to 10% by weight of the crosslinked hyaluronic acid, wherein the crosslinked hyaluronic acid is crosslinked with 1,4-butanediol diglycidyl ether and has a degree of modification of about 1.0 mole %; (b) 0.01 to 5% by weight of the non-crosslinked hyaluronic acid; (c) 0.1 to 10% by weight of 6-paradol; and (d) 0.1 to 10% by weight of Plantago lanceolate leaf extract. ### Claim 18 (depends on 12) The composition according to claim 12, wherein the vesicles are cationic vesicles, non-ionic vesicles, or a combination thereof. ### Claim 19 (depends on 1) The composition according to claim 1, wherein the composition is formulated for topical or parenteral application. ### Claim 20 (depends on 1) A method of caring for skin or reducing the effects of skin ageing, comprising topically applying a composition according to claim 1 to the skin of a human subject in need thereof.