# US 2019/0313952 A1 · Analyte sensing biointerface

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- Number: US 2019/0313952 A1
- Document ID: US20190313952A1
- Status: Published application
- Kind: A1
- Application number: 16/455,468
- Filed: 2019-06-27
- Published: 2019-10-17
- Earliest claimed: 2005-04-15
- Assignees: DexCom, Inc.
- Applicants: DexCom, Inc.
- Inventors: Peter C. Simpson; James H. Brauker
- Web page: https://patentgrep.com/patent/US20190313952A1

## CPC

- A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement}
- A61B 5/1486: using enzyme electrodes, e.g. with immobilised oxidase
- A61B 5/14865: {invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors}
- C12Q 1/001: {Enzyme electrodes}
- C12Q 1/006: {for glucose}
- A61B 5/0031: {Implanted circuitry}
- B33Y 80/00: Products made by additive manufacturing
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- B33Y: ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING

## Abstract

Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.

## Claims

### Claim 1

An implantable continuous glucose sensor system, comprising:
a working electrode configured to measure a signal indicative of a glucose concentration;
a membrane disposed on the working electrode, wherein the membrane comprises a biointerface, wherein the biointerface comprises an electrically conductive material, wherein the biointerface is configured to promote a foreign body response that will not substantially attack or attempt to block sensing of glucose; and
electronics electrically coupled to the working electrode.

### Claim 2 (depends on 1)

The sensor of claim 1, wherein the biointerface comprises an enzyme.

### Claim 3 (depends on 2)

The sensor of claim 2, wherein the biointerface further comprises a resistance domain disposed over the enzyme.

### Claim 4 (depends on 1)

The sensor of claim 1, wherein the biointerface further comprises a bioactive agent.

### Claim 5 (depends on 1)

The sensor of claim 1, wherein the biointerface is substantially planar.