# US 2019/0313637 A1 · Stabilization of particles coated with non-amphoteric, quaternizable and water-soluble polymers using a dispersing component

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- Number: US 2019/0313637 A1
- Document ID: US20190313637A1
- Status: Published application
- Kind: A1
- Application number: 16/472,531
- Filed: 2017-12-21
- Published: 2019-10-17
- Earliest claimed: 2016-12-23
- Assignees: BASF SE
- Applicants: BASF SE
- Inventors: Hans-Peter Seelmann-Eggebert; Joachim Bentele; Simon Poulton
- Web page: https://patentgrep.com/patent/US20190313637A1

## CPC

- A01N 25/10: Macromolecular compounds
- A01N 25/04: Dispersions, {emulsions, suspoemulsions, suspension concentrates} or gels (foams A01N25/16)
- A01N 25/26: in coated particulate form
- A01N 25/28: Microcapsules {or nanocapsules}
- A01N 25/30: characterised by the surfactants
- A01N 37/34: Nitriles
- A01N 43/40: six-membered rings
- A01N 43/54: 1,3-Diazines; Hydrogenated 1,3-diazines
- A01N 43/647: Triazoles; Hydrogenated triazoles
- A61K 8/0241: {Containing particulates characterized by their shape and/or structure (see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes)}
- A61K 8/11: Encapsulated compositions
- A61K 8/91: Graft copolymers (A61K8/89 takes precedence)
- A61P 33/14: Ectoparasiticides, e.g. scabicides
- A61Q 19/00: Preparations for care of the skin
- A61K 2800/10: General cosmetic use
- A61K 2800/412: Microsized, i.e. having sizes between 0.1 and 100 microns
- A61K 2800/5426: cationic
- A61K 2800/624: by macromolecular compounds
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Described herein is an aqueous composition including particles coated with at least one non-amphoteric, quaternizable polymer which is water soluble at 20° C., and at least one dispersing component, where the dispersing component includes a dispersing agent selected from an amphiphilic graft polymer based on water-soluble polyalkylene oxides (A) as a graft base and side chains formed by polymerization of a vinyl ester component (B), the polymer having an average of ≤1 graft site per 50 alkylene oxide units and a mean molar mass Mw of from 3000 to 100 000.

## Claims

### Claim 1

An aqueous composition comprising:
particles coated with at least one non-amphoteric, quaternizable polymer which is water soluble at 20° C., and
at least one dispersing component wherein the dispersing component comprises a dispersing agent selected from an amphiphilic graft polymer based on water soluble polyalkylene oxides (A) as a graft base and side chains formed by polymerization of a vinyl ester component (B), said polymer having an average of ≤1 graft site per 50 alkylene oxide units and a mean molar mass Mw of from 3000 to 100 000.

### Claim 2 (depends on 1)

The aqueous composition according to claim 1, wherein the amphiphilic graft polymer has a polydispersity Mw/Mn of <3.

### Claim 3 (depends on 1)

The aqueous composition according to claim 1, wherein the amphiphilic graft polymer comprises <10 wt % of polyvinyl ester (B) in ungrafted form.

### Claim 4 (depends on 1)

The aqueous composition according to claim 1, wherein the amphiphilic graft polymer has:
(A) from 20 to 70 wt % of the water-soluble polyalkylene oxide as the graft base; and
(B) side chains formed by free-radical polymerization of from 30 to 80 wt % of the vinyl ester component, composed of:
(B1) from 70 to 100% wt % of vinyl acetate and/or vinyl propionate; and
(B2) from 0 to 30 wt % of a further ethylenically unsaturated monomer
in the presence of (A).

### Claim 5 (depends on 1)

The aqueous composition according to claim 1, wherein the amphiphilic graft polymer comprises from 25 to 60 wt % of the graft base (A) and from 40 to 75 wt % of the vinyl ester component (B).

### Claim 6 (depends on 4)

The aqueous composition according to claim 4, wherein the vinyl ester component (B) of the amphiphilic graft polymer comprises from 70 to 100 wt % of vinyl acetate (B1) and from 0 to 30 wt % of a C1 to C8 alkyl acrylate (B2).

### Claim 7 (depends on 1)

The aqueous composition according to claim 1, wherein the dispersing agent is selected from an amphiphilic graft polymer obtained from a reaction of polyethylene oxide 6000 and vinyl acetate with a weight ratio of PEG 6000 to vinyl acetate of 40 to 60, and the dispersing component optionally comprises further co-dispersing agents.

### Claim 8 (depends on 1)

The aqueous composition according to claim 1, wherein the particles are selected from the group consisting of organic compounds.

### Claim 9 (depends on 1)

The aqueous composition according to claim 1, wherein the particles are selected from the group consisting of pesticides.

### Claim 10 (depends on 9)

The aqueous composition according to claim 9, wherein the pesticide is selected from the group consisting of Deltamethrin, Boscalid, Fluxapyroxad, Chlorothalonil, Epoxiconazole, Mefentrifluconazole, Strobilurins, like Azoxystrobin or Dimoxystrobin, and combinations thereof.

### Claim 11 (depends on 1)

The aqueous composition according to claim 1, wherein the non-amphoteric, quaternizable polymer being water soluble at 20° C. is selected from the group consisting of polyvinylamines, polyvinylamidoamines, polyethyleneimines, polypropyleneimines, polyamidoamines or polyureaamines, cationic copolymers comprising polymerisable monomers selected from the group consisting of vinylpyrrolidone, methacrylamide, vinyl imidazole, quaternized vinyl imidazole and combinations thereof, cationic copolymers comprising the cationic copolymers comprising polymerizable monomers selected from the group consisting of vinylpyrrolidone and quaternized vinyl imidazole, cationic copolymers comprising polymerizable monomers selected from the group consisting of vinylpyrrolidone and quaternized dimethylaminoethyl methacrylate (DMAEMA), cationic copolymers comprising polymerizable monomers selected from the group consisting of vinyl caprolactam, vinylpyrrolidone and quaternized vinyl imidazole, and combinations of said polymers.

### Claim 12 (depends on 1)

The aqueous composition according to claim 1, wherein the particles have a median particle size (D50) in a range of 0.1 to 50 μm and/or a median particle size (D90) in a range of 0.1 to 50 μm as measured with a Malvern Mastersizer 3000.

### Claim 13 (depends on 1)

The aqueous composition according to claim 1, comprising:
1.0 to 50.0 wt % of the particles coated with at least one non-amphoteric, quaternizable polymer which is water soluble at 20° C.; and
0.1 to 15.0 wt % of the at least one dispersing component, wherein the dispersing component comprises a dispersing agent selected from an amphiphilic graft polymer based on water soluble polyalkylene oxides (A) as a graft base and side chains formed by polymerization of a vinyl ester component (B), said polymer having an average of ≤1 graft site per 50 alkylene oxide units and a mean molar mass Mw of from 3000 to 100 000 wt %.

### Claim 14 (depends on 1)

A method of using the aqueous composition according to claim 1, the method comprising using the aqueous composition for a preparation of an agrochemical, cosmetic or pharmaceutical formulation.

### Claim 15 (depends on 1)

A method of using at least one dispersing component according to claim 1, the method comprising using the at least one dispersing component for dispersing a non-amphoteric, quaternizable polymer which is water soluble at 20° C. in an aqueous composition.

### Claim 16 (depends on 1)

The aqueous composition according to claim 1, wherein the particles have a median particle size (D50) in a range of 0.5 to 20 μm and/or a median particle size (D90) in a range of 0.5 to 20 μm as measured with a Malvern Mastersizer 3000.

### Claim 17 (depends on 1)

The aqueous composition according to claim 1, wherein the particles have a median particle size (D50) in a range of 1.0 to 10 μm and/or a median particle size (D90) in a range of 1.0 to 15 μm as measured with a Malvern Mastersizer 3000.

### Claim 18 (depends on 1)

The aqueous composition according to claim 1, wherein the particles have a median particle size (D50) in a range of 1.5 to 5 μm and/or a median particle size (D90) in a range of 1.5 to 10 μm as measured with a Malvern Mastersizer 3000.