# US 2019/0313636 A1 · Tissue Bonding Insect Repellant > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2019/0313636 A1 - Document ID: US20190313636A1 - Status: Published application - Kind: A1 - Application number: 16/382,671 - Filed: 2019-04-12 - Published: 2019-10-17 - Earliest claimed: 2018-04-17 - Assignees: Hour 72 - Applicants: Hour 72 - Inventors: Michael Milbocker; Kenneth O. Rothaus - Web page: https://patentgrep.com/patent/US20190313636A1 ## CPC - A01N 25/10: Macromolecular compounds - A01N 25/34: Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group - A01N 25/04: Dispersions, {emulsions, suspoemulsions, suspension concentrates} or gels (foams A01N25/16) - A01N 37/26: containing the group [IMAGE cpc-sch-A01N-0936.gif]; Thio analogues thereof - A01N 65/00: Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof (containing compounds of determined constitution A01N27/00 - A01N59/00) - A01N 65/26: Meliaceae [Chinaberry or Mahogany family], e.g. mahogany, langsat or neem - A01N 65/28: Myrtaceae [Myrtle family], e.g. teatree or clove - A61K 8/87: Polyurethanes - D06M 15/568: Reaction products of isocyanates with polyethers - D06M 16/00: Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic - A61Q 17/02: containing insect repellants - Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - D06M: TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS - Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE ## Abstract The present disclosure generally provides topically applicable insect repelling compositions, and in some embodiments, topically applicable insect repelling and UV protecting compositions. The compositions comprise a polymerization product of a polyol, a diisocyanate and at least one insect-repelling compound. The resulting polymers advantageously bond superficially to skin or hair, thereby localizing repellents and preventing systemic absorption. While not being bound by theory, it is believed that the localization of repellants to the surface of the skin renders them safer, wherein such repellents are not vaporized and do not have a disagreeable odor. The repellants advantageously interact with tactile insect activity, thereby preventing parasitic activity, such as drawing blood or the communication of pathogens. ## Claims ### Claim 1 A topical insect repellent composition comprising: i) a polymerization product of a polyol, a diisocyanate and at least one insect-repelling compound, and ii) a carrier in an amount suitable for application to the skin or hair. ### Claim 2 (depends on 1) The composition of claim 1, wherein the polyol is an amphiphilic block copolymer of ethylene oxide and propylene oxide, wherein each block contains 10 to 60 carbon atoms. ### Claim 3 (depends on 1) The composition of claim 1, wherein the polymerization product comprises an NCO weight fraction of less than 20% of the total weight. ### Claim 4 (depends on 1) The composition of claim 1, wherein the polymerization product is a multi-armed polymer, wherein at least one arm comprises a terminal NCO group, and at least two other arms comprise the insect-repelling compound. ### Claim 5 (depends on 4) The composition of claim 4, wherein the multi-armed polymer is a three-armed polymer. ### Claim 6 (depends on 4) The composition of claim 4, wherein between 25 and 45% of the arms in the polymerization product are bonded to an alcohol obtained from citronella oil, between 25 and 45% of the arms are bonded to an alcohol obtained from lemon eucalyptus oil, and between 0 and 10% of the arms are bonded to an alcohol obtained from neem oil. ### Claim 7 (depends on 1) The composition of claim 1, wherein the polyol is a polymerization product of trimethylolpropane, diisocyanate and a poloxamer, such that the product is a polyol comprising 3 arms of poloxamer bonded to one trimethylolpropane. ### Claim 8 (depends on 1) The composition of claim 1, having a molecular weight between 1000 and 20,000 Dalton. ### Claim 9 (depends on 1) The composition of claim 1, comprising at least one terminal NCO group capable of bonding to skin, thereby preventing penetration of the insect repellent molecule into the deeper layers of the skin. ### Claim 10 (depends on 1) The composition of claim 1 wherein the polymerization product (i) bonds to skin via a covalent bond formed between the terminal NCO groups and the skin. ### Claim 11 (depends on 1) The composition of claim 1, wherein the polymerization product further comprises an ultra violet absorbing compound. ### Claim 12 (depends on 1) The composition of claim 1 wherein the carrier comprises a free insect repellent and a skin emollient. ### Claim 13 (depends on 12) The composition of claim 12, wherein the free insect repellent is selected from the group consisting of i) a synthetic insect repellent, ii) a natural insect repellent and iii) combinations thereof. ### Claim 14 (depends on 13) The composition of claim 13, wherein the synthetic insect repellant comprises DEET. ### Claim 15 A long-lasting insect repellent emulsion composition, comprising: (a) an insect repellent agent comprising a polymerization product of a polyol, a diisocyanate, and an insect repelling compound, present in an amount effective to provide 90% protection for at least 8 hours; (b) a free insect repellent present in an amount from about 7 wt % to about 33 wt % of the composition; (c) a nonaqueous based solvent; and (d) an emulsifying agent. ### Claim 16 (depends on 1, 15) The long lasting insect repellent composition of claim 15 prepared by a method comprising the steps of (a) preparing a nonaqueous liquid phase comprising a nonaqueous solvent; (b) preparing an oil phase comprising an insect repellent agent of claim 1, and an ethoxylated fatty acid ester; and (c) combining said oil phase with said nonaqueous phase to form a stable emulsion. ### Claim 17 A long lasting sunscreen and insect repellent composition for applying to the skin or hair of a mammal, comprising: (a) a nonaqueous sunscreen agent present in an amount effective to provide an SPF of from about 15 to about 30; (b) an insect repellent agent comprising a polymerization product of a polyol, a diisocyanate and an insect repellent, present in an amount of from about 12 wt % to about 22 wt %; (c) a nonaqueous solvent; and (d) an emulsifying agent in an amount effective to form a stable emulsion; wherein the composition will remain on skin or hair and provide insect repellent even after the skin or hair of the mammal on whom the composition has been applied has been submerged under water for at least about one hour. ### Claim 18 (depends on 17) The composition of claim 17, wherein the sunscreen agent comprises octyl methoxycinnamate, octyl salicylate, and oxybenzone. ### Claim 19 (depends on 17) The composition of claim 17, further comprising a thickening agent. ### Claim 20 (depends on 19) The composition of claim 19, further comprising a fragrance, an emollient, and a preservative.