Method for diagnosing complicated parapneumonic effusion
AssigneeTaoyuan Armed Forces General Hospital
InventorsKUO-AN WU, CHIA-YU YANG, CHIH-CHING WU, HSI-HSIEN LIN
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Abstract
A method for diagnosing complicated parapneumonic effusion is revealed. A sandwich enzyme-linked immunosorbent assay (ELISA) is used to measure a level of a target protein in a pleural effusion. Then the level is compared with a preset baseline corresponding to the target protein so as to determine whether the pleural effusion is a complicated parapneumonic effusion (CPPE). The target protein can be further used in combination with conventional CPPE biomarkers to improve sensitivity and specificity in clinical diagnosis of CPPE.
Claims12
A method for diagnosing complicated parapneumonic effusion comprising the steps of:
- getting a pleural effusion;
- measuring a level of a target protein in the pleural effusion and the target protein being selected from the group consisting of bactericidal/permeability-increasing protein (BPI), azurocidin (AZU1), and a combination thereof;
- comparing the level with a preset baseline to get a comparison result;
- and
- determining whether the pleural effusion is a complicated parapneumonic effusion according to the comparison result.
A method for diagnosing complicated parapneumonic effusion comprising the steps of:
- getting a pleural effusion;
- measuring a bactericidal/permeability-increasing protein (BPI) level in the pleural effusion;
- comparing the bactericidal/permeability-increasing protein (BPI) level with a first preset baseline;
- measuring a lactate dehydrogenase (LDH) level in the pleural effusion when the bactericidal/permeability-increasing protein (BPI) level is lower than the first preset baseline;
- comparing the lactate dehydrogenase (LDH) level with a second preset baseline;
- and
- determining the pleural effusion to be a complicated parapneumonic effusion when the lactate dehydrogenase (LDH) level is higher than the second preset baseline.
Dependencies are inferred from the claim text.