Methods for colorimetric endpoint detection and multiple analyte titration systems
AssigneeEcolab USA Inc.
InventorsPaul R. Kraus, John Wilhelm Bolduc, Robert J. Ryther
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Abstract
Systems for quantifying one or more target analyte concentrations in a process solution are provided and can be used, for example, in methods for quantifying a target analyte concentration. These systems and methods include continuous and batchwise automated titration methods that use titration chemistries to measure the target analyte concentration in the process solution using a multiwavelength detector. The methods provide for efficient and robust automated titration methods for a variety of target analytes and can include methods that analyze more than one analyte and that provide for a dynamic range for measurement of more than one target analyte concentration.
Claims28
An automated titration system comprising
- a reaction manifold for mixing a sample stream containing an unknown concentration of an analyte with a first titrant;
- a sample pump for pumping the sample stream into the reaction manifold;
- a first titrant pump for pumping the first titrant into the reaction manifold to contact the sample stream;
- a multi-wavelength detector for detecting a first titration endpoint of the reaction between the analyte and the first titrant;
- and
- a controller communicatively coupled to the sample pump, the first titrant pump, and the detector,
- wherein the controller controls the sample pump to set the flow rate of the sample stream, controls the first titrant pump to set the flow rate of the first titrant, and receives data from the detector to detect the first titration endpoint for the reaction between the analyte and the first titrant and determine the analyte concentration at the first titration endpoint.
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A method for quantification of a target analyte concentration in a sample stream comprising:
- adding the sample to an analyzer comprising a manifold and a multi-wavelength detector;
- quantifying the target analyte concentration by adding a titrant to the analyzer and setting a titrant concentration change by changing the titrant concentration through increasing or decreasing a flow rate of the titrant over a specified range;
- and
- detecting a titration endpoint for the reaction between the target analyte in the sample stream and the titrant within a specified target analyte concentration range;
- wherein the sample stream comprises two or more analytes.
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Dependencies are inferred from the claim text.