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US 2019/0309062 A1Published application
Methods And Agents For The Diagnosis And Treatment Of Hepatocellular Carcinoma
AssigneeCircular Commitment Company
InventorsKuo-Jang Kao, Andrew T. Huang
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Abstract
The present invention relates to methods of diagnosing and methods of treating hepatocellular carcinoma in a subject. The invention also relates to antagonists of PLVAP proteins, such as antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising antagonists of PLVAP proteins. The invention further relates to humanized antibodies that specifically bind PLVAP protein.
Claims7
An isolated nucleic acid encoding:
- i) an isolated polypeptide comprising:
- 1) an antibody variable domain that comprises:
- a) a CDR1 consisting of SEQ ID NO:5;
- b) a CDR2 consisting of SEQ ID NO:6;
- and
- c) a CDR3 consisting of SEQ ID NO:7;
- and
- 2) an antibody variable domain that comprises:
- d) a CDR1 consisting of SEQ ID NO:10;
- e) a CDR2 consisting of SEQ ID NO:11;
- and
- f) a CDR3 consisting of SEQ ID NO:12;
- ii) an isolated polypeptide comprising:
- 1) an antibody variable domain that comprises:
- a) a CDR1 consisting of SEQ ID NO:15;
- b) a CDR2 consisting of SEQ ID NO:16;
- and
- c) a CDR3 consisting of SEQ ID NO:17;
- and
- 2) an antibody variable domain that comprises:
- d) a CDR1 consisting of SEQ ID NO:20;
- e) a CDR2 consisting of SEQ ID NO:21;
- and
- f) a CDR3 consisting of SEQ ID NO:22;
- or
- iii) an isolated polypeptide that is an isolated monoclonal antibody that specifically binds to SEQ ID NO:23 with the epitopic specificity of monoclonal antibody KFCC-GY4 or monoclonal antibody KFCC-GY5.
23 more elements
Dependencies are inferred from the claim text.