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US 2019/0302120 A1Published application
Methods for Detection, Staging, and Surveillance of Colorectal Adenomas and Carcinomas
AssigneeWisconsin Alumni Research Foundation
InventorsMichael Richard Sussman, Melanie Mae Ivancic, Gregory D Kennedy, William Franklin Dove, Perry Joseph Pickhardt, Mark Reichelderfer
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Abstract
This invention provides minimally invasive methods, reagents, diagnostic and prognostic markers useful for staging, prognosis and surveillance of colorectal cancers, and therapeutic intervention in individuals with colorectal cancers, or individuals who may be susceptible to developing colorectal cancers.
Claims38
A method for detecting one or a plurality of protein biomarkers in a biosample, the method comprising:
- (a) assaying a biosample for one or a plurality of protein biomarkers, wherein the protein biomarkers are leucine-rich alpha-2-glycoprotein, peptidase inhibitor 16, CD44, cadherin 2, C-reactive protein, dipeptidyl peptidase 4, inter-alpha trypsin inhibitor, heavy chain H4, inter-alpha trypsin inhibitor, heavy chain H3, coagulation factor V, epidermal growth factor receptor, Fetuin-B, hemopexin, serum amyloid P component, vitamin D binding protein, complement factor I, superoxide dismutase 3, vitronectin, thrombospondin-4 or quiescin sulfhydryl oxidase 1;
- and
- (b) detecting the level of one or a plurality of the protein biomarkers in the biosample.
A method of identifying a subject having colorectal cancer comprising,
- detecting one or a plurality of protein biomarkers in a biosample from the subject,
- wherein the one or a plurality of protein biomarkers comprises leucine-rich alpha-2-glycoprotein, peptidase inhibitor 16, CD44, C-reactive protein, dipeptidyl peptidase 4, inter-alpha trypsin inhibitor, heavy chain H4, inter-alpha trypsin inhibitor, heavy chain H3, coagulation factor V, epidermal growth factor receptor, Fetuin-B, hemopexin, or quiescin sulfhydryl oxidase 1.
Dependencies are inferred from the claim text.