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US 2019/0293667 A1Published application
Solid Phase Extraction, Derivatization with Crown Ethers, and Mass Spectrometry, Methods, Reagents and Kits
AssigneeTecan Sp, Inc.
InventorsQi Huang, Philip Dimson, Emmanuel Luis Maloles Chanco
Life of this patent
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Abstract
The present disclosure is directed to methods reagents and kits for solid phase extraction, derivatization with crown ether containing derivatizing agents, and mass spectrometry of the derivatized analytes.
Claims23
A method for determining the presence of one or more analytes in a test sample, the method comprising:
- a) extraction and purification of the one or more analytes from the test sample with one or more of solid phase extraction, supported liquid extraction (SLP), and liquid liquid extraction (LLP);
- b) derivatization of the one or more analytes with a crown-ether derivatizing agent;
- and
- c) detection of the one or more derivatized analytes using LC-MS/MS.
1 more element
A derivatization reagent for mass spectrometry having a derivatizing agent comprising:
- a crown-ether, a connector, and an analyte-binding functional group.
Dependencies are inferred from the claim text.