Immune modulating genes for prognosis, diagnosis and treatment of metastatic disease, and drug identification methods thereof
AssigneeCedars-Sinai Medical Center
InventorRichard Essner
Life of this patent
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Abstract
Immune-modulating genes are provided for prognosis and diagnosis of metastases or reoccurrence of cancer, as well as methods of prognosis, diagnosis, prophylaxis and treatment of cancer metastases.
Claims20
A method of detecting chemokine C—X—C motif ligand (CXCL) 1 (CXCL1) in a subject who has or has had a cancer or a symptom thereof, said method comprising:
- obtaining a biological sample from the subject;
- detecting whether the expression level of CXCL1 in the biological sample is higher than a control level.
A method of detecting interleukin 1 alpha (IL1A) and receptor-type tyrosine-protein phosphatase kappa (PTPRK) and the Clark's Level in a subject who has or has had melanoma or a symptom thereof, comprising:
- obtaining a melanoma sample from the subject;
- detecting whether the expression levels of IL1A and PTPRK and the Clark's Level are higher than control levels, wherein the control is a subject free from melanoma, a skin tissue sample free from melanoma, or a melanoma sample of a subject who does not have metastasis or reoccurrence of melanoma.
A method of screening for a candidate agent for treating, reducing the likelihood or severity of, or slowing the progression of metastases or reoccurrence of melanoma in a subject, comprising:
- contacting the candidate agent with a melanoma cell line or tissue that expresses one or more of chemokine (C—X—C motif) ligand 1 (CXCL1), CXCL2, E3 ubiquitin-protein ligase CBL (CBL) and cluster of differentiation 276 (CD276),
- wherein after the contact a reduced activity or reduced expression in one or more of CXCL1, CXCL2, CBL, and CD276 compared to before the contact identifies a candidate agent for treating, reducing the likelihood or severity of, or slowing the progression of metastases or reoccurrence of melanoma.
Dependencies are inferred from the claim text.