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US 2019/0292592 A1Published application
Normalization of nucleic acid libraries
AssigneeBecton, Dickinson and Company
InventorsEleen Shum, Glenn Fu, Craig Betts
Life of this patent
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Abstract
This disclosure provides methods and compositions for removing one or more high abundance species from a plurality of nucleic acid molecules. In some embodiments, the methods and compositions can be used for normalizing nucleic acid libraries. In some embodiments, molecular labels are used in conjunction with the methods and compositions disclosed herein to improve sequencing efficiency.
Claims15
-122. (canceled)
A composition, comprising:
- a plurality of first oligonucleotides comprising an affinity moiety;
- and
- a plurality of capture molecules immobilized on one or more solid supports, wherein the capture molecules are configured to specifically bind to the affinity moiety.
Dependencies are inferred from the claim text.