Substrates and optical systems and methods of use thereof
AssigneePacific Biosciences of California, Inc.
InventorsCheng Frank Zhong, Paul Lundquist, Mathieu Foquet, Jonas Korlach, Hovig Bayandorian
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Abstract
This invention provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
Claims17
1-44. (canceled)
An analytic device, comprising:
- a waveguide substrate comprising a waveguide core and a waveguide cladding;
- an opaque mask layer deposited on a top surface of the waveguide substrate;
- and
- a nanohole extending through the opaque mask layer and into the waveguide cladding but not into the waveguide core;
- wherein the nanohole comprises an analyte region disposed sufficiently proximal to the waveguide core to be illuminated by an evanescent field emanating from the waveguide core when optical energy is passed therethrough.
Dependencies are inferred from the claim text.