Methods Of Identifying And Treating Poor-Prognosis Cancers
AssigneeThe Trustees of Princeton University
InventorsYibin Kang, Guohong Hu
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Abstract
The present invention relates generally to methods for identifying cancer patients with a poor prognosis, and to therapeutic modalities for improving prognosis by combating metastasis and abrogating chemoresistance in cancer cells. Embodiments of the present invention provide an objective means of prognostication regarding the long-term outcome of an incident of cancer, breast cancer in particular. Therapeutic modalities include immunotherapy and anti-sense therapy. Prognosis is determined by measuring the number of copies of the metadherin gene in the patient's cells.
Claims20
A method of treating a cancer in an individual, comprising:
- (a) administering to the individual an effective amount of a chemotherapeutic agent;
- (b) detecting genomic amplification and/or overexpression of a metadherin (MTDH) gene in a tumor sample of the individual;
- and
- (b) administering to the individual an effective amount of a MTDH inhibitor selected from the group consisting of an antisense molecule and a small molecule.
A method of treating a cancer in an individual, wherein the individual has genomic amplification and/or overexpression of a metadherin (MTDH) gene in a tumor sample of the individual, comprising:
- administering to the individual an effective amount of a chemotherapeutic agent and an effective amount of an MTDH inhibitor selected from the group consisting of an antisense molecule and a small molecule.
Dependencies are inferred from the claim text.