RNAi Agents for Hepatitis B Virus Infection

A composition comprising an RNAi agent for inhibiting expression of a Hepatitis B Virus (HBV) gent wherein the RNAi agent comprises:

• (a) an antisense strand comprising a nucleotide sequence of any one of the following:
• SEQ ID NO:100, SEQ ID NO:126, SEQ ID NO:127, SEQ ID NO:128, SEQ ID NO:171, SEQ ID NO:179, and SEQ ID NO:180, and
• a sense strand comprising a nucleotide sequence of any one of the following:
• SEQ ID NO:229, SEQ ID NO:252, SEQ ID NO:253, SEQ ID NO:273, SEQ ID NO:302, and SEQ ID NO:319;
• or
• (b) an antisense strand comprising a nucleotide sequence of any one of the following:
• SEQ ID NO:
• 140 and SEQ ID NO:188, and
• a sense strand comprising a nucleotide sequence of any one of the following:
• SEQ ID NO:262, SEQ ID NO:271, SEQ ID NO:274, and SEQ ID NO:328.