5'-triphosphate oligoribonucleotides
AssigneeOregon Health & Science University
InventorJohn Hiscott
Life of this patent
Estimating the term…
Abstract
Disclosed herein are synthetic oligoribonucleotides that form hairpin loop structures. The oligoribonucleotides can be used in the treatment of viral infection including prophylactic treatments. The oligoribonucleotides can also be used as adjuvants.
Claims12
A synthetic oligoribonucleotide at least 41 nucleotides in length that can form a hairpin structure comprising at least 17 base pairs, the synthetic oligonucleotide comprising a 5′ end triphosphate group, wherein the synthetic oligoribonucleotide comprises any of SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16, or SEQ ID NO:
- 17.
The synthetic oligoribonucleotide of claim 6 comprising SEQ ID NO:
- 14 or SEQ ID NO:
- 17.
The pharmaceutical composition of claim 8 further comprising a viral antigen.
Dependencies are inferred from the claim text.