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US 2019/0292522 A1Published application
Notch activation enhances mesenchymal stem cell sheet osteogenic potential by inhibition of cellular senescence
OwnerYufeng DONGinventor
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Abstract
A method of retaining multi-potency in stem cells comprising one of reducing p16RNA expression and increasing Hes1 expression. A therapeutic comprising a high density sheet of stem cells wherein the stem cells are Notch activated. A method of treating bone injury comprising administering stem cells that are Notch activated. Notch is activated by adding Jagged1.
Claims16
A method of retaining multi-potency in stem cells comprising:
- one of reducing p16RNA expression and increasing Hes1 expression.
A therapeutic comprising:
- a high density sheet of stem cells;
- wherein the stem cells are Notch activated.
A method of treating bone injury comprising:
- administering stem cells that are Notch activated.
Dependencies are inferred from the claim text.