Compounds and Methods to Measure Metabolic Function and Restore Normal Metabolic Function
OwnerKenneth Walsh, Noriyuki Ouchiinventors
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Abstract
The invention relates to treatment to restore normal metabolic function, including but not limited to normal glucose levels. The invention in one embodiment contemplates methods of reducing elevated glucose levels in subjects with elevated glucose levels by administering a composition comprising at least a portion of human Sfrp5. The invention in one embodiment contemplates methods of reducing elevated glucose levels in subjects with elevated glucose levels by administering a composition comprising an inhibitor of Wnt5a, including but not limited to an antibody inhibitor.
Claims15
A method of reducing elevated glucose levels, comprising:
- a) providing a subject with elevated glucose levels and a composition comprising at least a portion of human Sfrp5;
- b) administering said composition to said subject;
- and
- c) measuring said glucose levels of said subject until they are reduced.
A method of reducing elevated glucose levels, comprising:
- a) providing a subject with elevated glucose levels and a composition comprising an antibody or portion thereof reactive with human Wnt5a;
- b) administering said composition to said subject;
- and
- c) measuring said glucose levels of said subject until they are reduced.
A method of measuring metabolic function, comprising:
- a) providing i) a sample from a subject and ii) a reagent for measuring human Sfrp5 protein or human Sfrp5 nucleic acid;
- b) measuring the level of Sfrp5 protein or nucleic acid as an indicator of metabolic function.
Dependencies are inferred from the claim text.