Methods of reversing cachexia and prolonging survival comprising administering a gdf15 modulator and an anti-cancer agent
AssigneeAVEO Pharmaceuticals, Inc.
InventorsJeno Gyuris, Lorena Lerner, Jie Lin
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Abstract
Methods are provided for improved treatment of subjects with cancer anorexia-cachexia syndrome, comprising treatment with a combination of at least one anti-cancer agent and at least one GDF15 modulator. Methods are further provided for improved treatment of subjects with anti-cancer agents which induce cachexia, comprising further treating the subject with at least one GDF15 modulator.
Claims14
A method for increasing the overall survival in a subject having cancer anorexia-cachexia syndrome, comprising treating the subject with at least one anti-cancer agent and at least one GDF15 modulator.
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A method for increasing the overall survival in a subject bearing a cachexia-inducing tumor, comprising treating the subject with at least one anti-cancer agent and at least one GDF15 modulator.
A method of treating a subject with cancer anorexia-cachexia syndrome, the method comprising administering a GDF15 modulator and an anti-cancer agent, wherein administration of the GDF15 modulator and the anti-cancer agent prolongs mean survival in a first patient population with cancer anorexia-cachexia syndrome relative to a second patient population with cancer anorexia-cachexia syndrome who do not receive the GDF15 modulator.
Dependencies are inferred from the claim text.