Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau

A method for the prophylaxis and/or treatment of a subject for Alzheimer's disease, or the memory and/or cognitive disorders associated with tau, the method comprising:

• utilizing an antibody or an antigen-binding fragment thereof in the prophylaxis and/or treatment of Alzheimer's disease, or memory and/or cognitive disorders associated with tau in a subject, wherein the antibody is selected from the group consisting of
• a) an antibody comprising a heavy chain CDR1 region of SEQ ID NO:201, a heavy chain CDR2 region comprising SEQ ID NO:202, and a heavy chain CDR3 region comprising SEQ ID NO:203, a light chain CDR1 region comprising SEQ ID NO:204, a light chain CDR2 region comprising SEQ ID NO:205 and a light chain CDR3 region comprising SEQ ID NO:206,
• b) an antibody comprising a heavy chain CDR1 region comprising SEQ ID NO:207, a heavy chain CDR2 region comprising SEQ ID NO:208, and a heavy chain CDR3 region comprising SEQ ID NO:209, a light chain CDR1 region comprising SEQ ID NO:210, a light chain CDR2 region comprising SEQ ID NO:211 and a light chain CDR3 region comprising SEQ ID NO:212,
• c) an antibody comprising a heavy chain CDR1 region comprising SEQ ID NO:222, a heavy chain CDR2 region comprising SEQ ID NO:223, and a heavy chain CDR3 region comprising SEQ ID NO:224, a light chain CDR1 region comprising SEQ ID NO:225, a light chain CDR2 region comprising SEQ ID NO:173 and a light chain CDR3 region comprising SEQ ID NO:226;
• d) an antibody comprising a heavy chain CDR1 region comprising SEQ ID NO:238, a heavy chain CDR2 region comprising SEQ ID NO:
• 239, and a heavy chain CDR3 region comprising SEQ ID NO:240, a light chain CDR1 region comprising SEQ ID NO:241, a light chain CDR2 region comprising SEQ ID NO:173 and a light chain CDR3 region comprising SEQ ID NO:242,
• e) an antibody comprising a heavy chain CDR1 region comprising SEQ ID NO:243, a heavy chain CDR2 region comprising SEQ ID NO:244, and a heavy chain CDR3 region comprising SEQ ID NO:245, a light chain CDR1 region comprising SEQ ID NO:246, a light chain CDR2 region comprising SEQ ID NO:
• 173 and a light chain CDR3 region comprising SEQ ID NO:212,
• f) an antibody comprising a heavy chain CDR1 region comprising SEQ ID NO:243, a heavy chain CDR2 region comprising SEQ ID NO:247, and a heavy chain CDR3 region comprising SEQ ID NO:248, a light chain CDR1 region comprising SEQ ID NO:249, a light chain CDR2 region comprising SEQ ID NO:173 and a light chain CDR3 region comprising SEQ ID NO:212, and
• g) an antibody comprising a heavy chain CDR1 region comprising SEQ ID NO:250, a heavy chain CDR2 region comprising SEQ ID NO:251, and a heavy chain CDR3 region comprising SEQ ID NO:252, a light chain CDR1 region comprising SEQ ID NO:254, a light chain CDR2 region comprising SEQ ID NO:254 and a light chain CDR3 region comprising SEQ ID NO:255.