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US 2019/0292201 A1Published application
Process for the preparation of (s)-2-((2-((s)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino) prop an amide
AssigneeGenentech, Inc.
InventorsFrancis GOSSELIN, Chong HAN, Theresa CRAVILLION, Sean M. KELLY, Scott SAVAGE
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Abstract
Methods of making benzoxazepin oxazolidinone compounds as well as synthetic intermediates are described, including compound 18, having the structure:
Claims11
A process for the preparation of compound 18, having the structure:
- comprising reacting compound 17, having the structure:
- with ammonia and a peptide coupling reagent selected from the group consisting of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide;
- N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride/1-hydroxybenzotriazole;
- and 1,1′-carbonyldiimidazole (CDI), to form compound 18.
1 more element
Ammonium (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propionate (compound 17), having the structure:
Dependencies are inferred from the claim text.