Substituted pyrrolizine compounds and uses thereof

A compound of Formula

• or a pharmaceutically acceptable salt thereof,
• wherein:
• R1 is C1-6 alkyl optionally substituted with 1 to 3 R1A, C3-8 cycloalkyl optionally substituted with 1 to 4 R1B, or 3 to 8 membered monocyclic or bicyclic heterocyclyl having 1 to 3 heteroatoms selected from N, O, and S, optionally substituted with 1 to 3 R1C;
• each R1A is independently halogen, —OH, —CN, C1-2 haloalkyl, —C(O)NRXRY, C6-10 aryl optionally substituted with 1 to 3 R1D, or a 5 to 8 membered heteroaryl having 1 to 3 heteroatoms selected from N, O, and S, optionally substituted with 1 to 3 R1D, provided no more than 1 R1A is C6-10 aryl optionally substituted with 1 to 3 R1D or 5 to 8 membered heteroaryl having 1 to 3 heteroatoms selected from N, O, and S;
• each R1B is independently —CN, halogen, C1-6 alkyl optionally substituted with 1 to 3 —OH or —NRaRb, C2-4 alkynyl, C1-4 alkoxy, C1-2 haloalkyl, C3-6 cycloalkyl, —C(O)NRXRY, or a 5 to 8 membered heteroaryl having 1 to 3 heteroatoms selected from N, O, and S optionally substituted with 1 to 3 R1D, provided no more than 1 R1B is C3-6 cycloalkyl or 5 to 8 membered heteroaryl having 1 to 3 heteroatoms selected from N, O, and S;
• each R1C is independently C1-6 alkyl, oxo, C1-4 haloalkyl, —C(O)H, —C(O)C1-4 alkyl, —C(O)OC1-4 alkyl, —C(O)NRXRY, or a 5 to 12 membered heteroaryl having 1 to 3 heteroatoms selected from N, O, and S optionally substituted with 1 to 3 R1D, provided no more than 1 R1C is a 5 to 12 membered heteroaryl having 1 to 3 heteroatoms selected from N, O, and S;
• each RX is independently —H, C3-6 cycloalkyl, C1-6 alkyl optionally substituted with 1 to 3 RZ, or 3 to 8 membered monocyclic or bicyclic heterocyclyl having 1 to 3 heteroatoms selected from N, O, and S, optionally substituted with 1 to 3 RZ;
• each RY is independently —H or C1-6 alkyl optionally substituted with 1 to 3 RZ;
• or RX and RY are taken together to form a 3 to 8 membered monocyclic or bicyclic heterocyclyl having 1 to 3 heteroatoms selected from N, O, and S, optionally substituted with 1 to 3 RZ;
• wherein each RZ is independently halogen, methyl, ethyl, oxo, —OH, —S(O)2C1-3 alkyl, or 3 to 8 membered monocyclic or bicyclic heterocyclyl having 1 to 3 heteroatoms selected from N, O, and S;
• each Ra is —H, C1-3 alkyl, or a 3 to 8 membered monocyclic or bicyclic heterocyclyl having 1 to 3 heteroatoms selected from N, O, and S, optionally substituted with 1 to 3 RZ;
• each Rb is —H or C1-3 alkyl;
• or
• Ra and Rb taken together form a 3 to 8 membered monocyclic or bicyclic heterocycle optionally substituted with 1 to 3 RZ;
• the moiety
• is a pyrrolidine or a 5-7 membered bicyclic heterocycle having one nitrogen, optionally substituted with 1 to 6 R2 groups;
• wherein each R2 is independently halogen, C1-3 alkyl, —OH, or —OC1-3 alkyl;
• R3 is —H, halogen, or C1-4 alkyl;
• R4 is C6-10 aryl optionally substituted with 1 to 5 R4A, or 5 to 12 membered heteroaryl having 1 to 3 heteroatoms selected from N, O, and S, optionally substituted with 1 to 4 R4B;
• and
• each R1D, R4A, and R4B are independently —CN, halogen, C1-4 alkyl optionally substituted with —Si(C1-4 alkyl)3, —OC1−0.4 alkyl, —OC1-4 haloalkyl, or C1-4 haloalkyl.