Compounds containing benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide or benzo[d][1,3]oxathiole 3,3-dioxide and methods/uses thereof as agonists of g protein-coupled receptor 119

A compound having formula (A-I):

• or an enantiomer, diastereomer, hydrate, solvate, or pharmaceutically acceptable salt of formula (A-I), or a prodrug or complex thereof, wherein:
• X1 is selected from the group consisting of O, and SO2;
• X2 is selected from the group consisting of O, and SO2;
• when X1 is O, X2 is not O;
• when X2 is O, X1 is not O;
• when X1 is SO2, X2 is not SO2;
• when X2 is SO2, X1 is not SO2;
• X3 is selected from the group consisting of CH, CF and N;
• X4 is at each occurrence is independently selected from the group consisting of CH and N;
• A is selected from the group consisting of
• R is selected from the group consisting of
• R1 is selected from the group consisting of hydrogen, C(O)O-tert-butyl, and
• R2a is selected from the group consisting of hydrogen and C1-6 alkyl;
• R2b is selected from the group consisting of hydrogen and C1-6 alkyl;
• R3 is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl, C(O)R9, C(O)NR10aR10b, CH2C(O)OR10a,
• R4 is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl, C(O)R9, C(O)OR10, C(O)NR10aR10b,
• R5 is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl, C(O)R9, C(O)OR10, C(O)NR10aR10b,
• R6 is selected from the group consisting of
• NHR11, and CH2NHR12;
• R7a is selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C3-7 branched alkyl, C1-6 haloalkyl, and C1-6 alkoxy;
• R7b is selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C3-7 branched alkyl, C1-6 haloalkyl, and C1-6 alkoxy;
• R7c is selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C3-7 branched alkyl, C1-6 haloalkyl, and C1-6 alkoxy;
• R8 is selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C3-7 branched alkyl, and C3-7 cycloalkyl;
• R9 is selected from the group consisting of C1-6 alkyl, C3-7 branched alkyl, and
• R10 is selected from the group consisting of C1-6 alkyl and C3-7 branched alkyl;
• R10a is selected from the group consisting of hydrogen, C1-6 alkyl, and C3-7 branched alkyl;
• R10b is selected from the group consisting of hydrogen, C1-6 alkyl, and C3-7 branched alkyl;
• R11 is selected from the group consisting of
• R12 is selected from the group consisting of
• R13a is at each occurrence independently selected from the group consisting of hydrogen, C1-6 alkyl, and C3-7 branched alkyl;
• R13b is at each occurrence independently selected from the group consisting of hydrogen, C1-6 alkyl, and C3-7 branched alkyl;
• R14a is at each occurrence independently selected from the group consisting of hydrogen, C1-6 alkyl, C3-7 branched alkyl, and C(O)O-tert-butyl;
• R14b is at each occurrence independently selected from the group consisting of hydrogen, C1-6 alkyl, and C3-7 branched alkyl;
• X5 is selected from the group consisting of N and CR7b;
• n1 is 1 or 2;
• n2 is 1 or 2;
• and m is 1, 2, 3, 4, 5, 6, or 7;
• with the proviso that the compound excludes any compound having formula (A-1a)
• wherein:
• R15 is:
• hydrogen;
• C1-C5 alkyl;
• halogen-substituted C1-C5 alkyl;
• acyl selected from the group C1-C5 alkyl(C═O) and phenyl(C═O);
• substituted heteroaryl representing a monocyclic aromatic group with two nitrogen atoms which is substituted by a halogen or (C1-C5) alkyl;
• (C1-C3) alkylsulphonyl;
• or phenylsulphonyl;
• and
• R16a, R16b, R16c and R16d are hydrogen or one or two substitutents simultaneously selected from halogen, (C1-C3) alkyl, halogen-substituted (C1-C3)alkyl, (C1-C3)alkylsulphonyl or cyano.

A compound, which is:

• 6-((3-fluoro-4-piperidin-4-ylmethoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• 6-((3-fluoro-4-((1-isopropylpiperidin-4-ylmethoxy)phenyl)-2H-benzo[1,3]oxathiole 3,3-dioxide;
• 6-((3-fluoro-4-((1-tert-butylpiperidin-4-ylmethoxy)phenyl)-2H-benzo[1,3]oxathiole 3,3-dioxide;
• 4-((4-3,3-dioxido-2H-benzo[d][1,3]oxathiol-6-yl)-2-fluorophenyoxy)methyl)-N,N-dimethylpiperidine-1-carboxamide;
• tert-butyl (2-(4-((4-(3,3-dioxido-2H-benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)piperidin-1-yl)-2-oxoethyl)carbamate;
• (2-(4-((4-(3,3-dioxido-2H-benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)piperidin-1-yl)ethan-1-one;
• tert-butyl (S)-(1-(4-((4-(3,3-dioxido-2H-benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)piperidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate;
• ((S)-2-amino-1-(4-((4-(3,3-dioxido-2H-benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)piperidin-1-yl)-)-3-methylbutan-1-one;
• 4-((4-3,3-dioxido-2H-benzo[d][1,3]oxathiol-6-yl)-2-fluorophenyoxy)methyl)-piperidine-1-carboxamide;
• 1-4-((4-3,3-dioxido-2H-benzo[1,3]oxathiol-6-yl)-2-fluorophenyoxy)methyl)-piperidin-1-yl)-2-methylpropan-1-one;
• ethyl-2-(4-{[4-(3,3-dioxido-2H-benzo[d][1,3]oxathiol-6-yl)-2-fluorophenyoxy)methyl)-piperidin-1-yl)acetic acid;
• 6-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• tert-butyl 4-(((5-(3,3-dioxido-2H-benzo[d][1,3]oxathiol-6-yl)pyrimidin-2-yl)oxy)methyl)piperidine-1-carboxylate;
• 6-(2-(piperidin-4-ylmethoxy)pyrimidin-5-yl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• 6-(2-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)methoxy)pyrimidin-5-yl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• 5-(4-((1-5-chloropyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• 6-(4-((1-(4-chloro-1,3,5-triazin-2-yl)piperidin-4-yl)methoxy)-3-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• 6-(4-((1-(1,3,5-triazin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• tert-butyl 3-((4-(3,3-dioxido-2H-benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)azetidine-1-carboxylate;
• 6-(4-(azetidin-3-ylmethoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• 6-(4-((1-(5-chloropyrimidin-2-yl)azetidin-3-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• 6-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)azetidin-3-yl)methoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• tert-butyl 4-(5-((4-(3,3-dioxido-2H-benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)thiazol-2-yl)piperidine-1-carboxylate;
• 6-(3-fluoro-4-((2-(piperidin-4-yl)thiazol-5-yl)methoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• 6-(4-((2-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)thiazol-5-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole-3,3-dioxide;
• 6-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• tert-butyl 4-(4-(3,3-dioxido-2H-benzo[d][1,3]oxathiol-6-yl)-2-fluorophenyl]piperazine-1-carboxylate;
• 6-(3-fluoro-4-(piperazine-1-yl)phenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• 6-(4-(5-chloropyrimidin-2-yl)piperazin-1-yl)-3-fluorophenyl-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• 6-(4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• 5-(4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl-2H-benzo[d][1,3]oxathiole3,3-dioxide;
• 6-(3-fluoro-4-(1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• 6-(3-fluoro-4-(1-(5-methoxypyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• (R)-6-(4-((1-(5-ethylpyrimidin-2-yl)pyrrolidin-2-yl)methoxy)-3-fluorophenyl-2H-benzo[d]oxathiole 3,3-dioxide;
• tert-butyl 4-(((2-(3,3-dioxido-2H-benzo[d][1,3]oxathiol-6-yl)pyrimidin-5-yl)oxy)methyl)piperidine-1-carboxylate;
• 6-(5-(piperidin-4-ylmethoxy)pyrimidin-2-yl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide hydrochloride;
• 6-(5-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)pyrimidin-2-yl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• (S)-6-(4-((1-(5-ethylpyrimidin-2-yl)pyrrolidin-2-yl)methoxy)-3-fluorophenyl-2H-benzo[d]oxathiole 3,3-dioxide;
• (S)-6-(4-((1-(5-ethylpyrimidin-2-yl)pyrrolidin-3-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• (S)-6-(4-((1-(5-chloropyrimidin-2-yl)pyrrolidin-3-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• (S)-6-(4-((1-(4-ethylpyrimidin-2-yl)pyrrolidin-3-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide;
• or a pharmaceutically acceptable form thereof.

A compound having formula (B-I):

• or an enantiomer, diastereomer, hydrate, solvate, or pharmaceutically acceptable salt of formula (B-I), or a prodrug or complex thereof, wherein:
• X1 is selected from the group consisting of O, S and SO;
• X2 is selected from the group consisting of O, S and SO;
• when X1 is O, X2 is not O;
• when X2 is O, X1 is not O;
• when X1 is S, X2 is not S;
• when X2 is S, X1 is not S;
• when X1 is SO, X2 is not SO;
• when X2 is SO, X1 is not SO;
• X3 is selected from the group consisting of CH, CF and N;
• X4 at each occurrence is independently selected from the group consisting of CH and N;
• A is selected from the group consisting of
• R is selected from the group consisting of
• R1 is selected from the group consisting of hydrogen, C(O)O-tert-butyl, and
• R2a is selected from the group consisting of hydrogen and C1-6 alkyl;
• R2b is selected from the group consisting of hydrogen and C1-6 alkyl;
• R3 is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl, C(O)R9, C(O)OR10, C(O)NR10aR10b, CH2C(O)OR10a,
• R4 is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl, C(O)R9, C(O)OR10, C(O)NR10aR10b,
• R5 is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl, C(O)R9, C(O)OR10, C(O)NR10aR10b,
• R6 is selected from the group consisting of
• NHR11, and CH2NHR12;
• R7a is selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C3-7 branched alkyl, C1-6 haloalkyl, and C1-6 alkoxy;
• R7b is selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C3-7 branched alkyl, C1-6 haloalkyl, and C1-6 alkoxy;
• R7c is selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C3-7 branched alkyl, C1-6 haloalkyl, and C1-6 alkoxy;
• R8 is selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C3-7 branched alkyl, and C3-7 cycloalkyl;
• R9 is selected from the group consisting of C1-6 alkyl, C3-7 branched alkyl, and
• R10 is selected from the group consisting of C1-6 alkyl and C3-7 branched alkyl;
• R10a is selected from the group consisting of hydrogen, C1-6 alkyl, and C3-7 branched alkyl;
• R10b is selected from the group consisting of hydrogen, C1-6 alkyl, and C3-7 branched alkyl;
• R11 is selected from the group consisting of
• R12 is selected from the group consisting of
• R13a is at each occurrence independently selected from the group consisting of hydrogen, C1-6 alkyl, and C3-7 branched alkyl;
• R13b is at each occurrence independently selected from the group consisting of hydrogen, C1-6 alkyl, and C3-7 branched alkyl;
• R14a is at each occurrence independently selected from the group consisting of hydrogen, C1-6 alkyl, C3-7 branched alkyl, and C(O)O-tert-butyl;
• R14b is at each occurrence independently selected from the group consisting of hydrogen, C1-6 alkyl, and C3-7 branched alkyl;
• X5 is selected from the group consisting of N and CR7b;
• n1 is 1 or 2;
• n2 is 1 or 2;
• and m is 1, 2, 3, 4, 5, 6, or 7.

A compound, which is:

• 5-(4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• 6-(4-((1-(5-ethylpyrimidin-2-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole-3-oxide;
• 1-(4-((2-fluoro-4-(3-oxido-2H-benzo[d][1,3]oxathiol-6-yl)phenoxy)methyl)-piperidin-1-yl)-3-methylbutane-1-one;
• 6-(3-fluoro-4-((1-(5-methoxypyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• 6-(4-((1-(4-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-(fluorophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• 2-(4-((4-benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)piperidin-1-yl)-4-ethylpyrimidine;
• 6-(4-((1-(5-ethoxypyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• 6-(3-fluoro-4-((1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• 6-(3-fluoro-4-((1-(5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)methoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• 6-(3-fluoro-4-(piperidin-4-yl)methoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• tert-butyl-4-((2-fluoro-4-(3-oxido-2H-benzo[d][1,3]oxathiol-6-yl)phenoxy)methyl) piperidine-1-carboxylate;
• (S)-6-(4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (R)-6-(4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• 6-(4-((1-(4-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• 4-((4-((benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)piperidine;
• 2-((4-((4-(benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)piperidin-1-yl)-5-ethylpyrimidine;
• 2-((4-((4-(benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)piperidin-1-yl)-5-isopropylpyrimidine;
• 2-(4-((4-((benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)piperidin-1-yl)-5-methoxpyrimidine;
• 1-(4-((4-(benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)piperidin-1-yl)-3-methylbutan-1-one;
• tert-butyl-(R)-4-((2-fluoro-4-(3-oxido-2H-benzo[d][1,3]oxathiol-6-yl)phenoxy)methyl) piperidine-1-carboxylate;
• (R)-6-(3-fluoro-4-(piperidin-4-ylmethoxy)phenyl)-2H-benzo[d][1.3]oxathiole 3-oxide;
• tert-butyl-(S)-4-((2-fluoro-4-(3-oxido-2H-benzo[d][1.3]oxathiol-6-yl)phenoxy)methyl) piperidine-1-carboxylate;
• (S)-6-(3-fluoro-4-(piperidin-4-ylmethoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (S)-6-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (S)-6-(3-fluoro-4-((1-5-isopropylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (S)-6-(3-fluoro-4-((1-5-methoxypyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (R)-6-(3-fluoro-4-((1-(5-methoxypyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (R)-6-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (R)-6-(3-fluoro-4-((1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• tert-butyl (R)-4-(((5-(3-oxido-2H-benzo[d][1,3]oxathiol-6-yl]pyrimidin-2-yl)oxy)methyl)piperidine-1-carboxylate;
• (R)-6-(2-(piperidin-4-ylmethoxy)pyrimidin-5-yl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (R)-6-(2-((1-(5-chloropyridin-2-yl)piperidin-4-yl)methoxy)pyrimidin-5-yl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (S)-6-(4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• tert-butyl (S)-4-(((5-(3-oxido-2H-benzo[d][1,3]oxathiol-6-yl)pyrimidin-2-yl)oxy)methyl)piperidine-1-carboxylate;
• (S)-6-(2-(piperidin-4-ylmethoxy)pyrimidin-5-yl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (S)-6-(2-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)methoxy)pyrimidin-5-yl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• tert-butyl (3R)-3-((2-fluoro-4-(3-oxido-2H-benzo[d][1,3]oxathiol-6-yl)phenoxy)methyl) pyrrolidine-1-carboxylate;
• 6-(3-fluoro-4(((R)-pyrrolidin-3-yl)methoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3-oxide 6-(4-(((R)-1-(5-Ethylpyrimidin-2-yl)pyrrolidin-3-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (R)-3-((4-benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)pyrrolidine;
• (R)-2-(3-((4-benzo[d][1,3]oxathiol-6-yl)-2-fluorophenoxy)methyl)pyrrolidin-1-yl)-5-ethylpyrimidine;
• (S)-6-(4-(((S)-1-(5-ethylpyrimidin-2-yl)pyrrolidin-3-yl)methoxy)-3-flurophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (R)-6-(4-(((S)-1-(5-ethylpyrimidin-2-yl)pyrrolidin-3-yl)methoxy-3-flurophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (S)-6-(4-(((R)-1-(5-ethylpyrimidin-2-yl)pyrrolidin-3-yl)methoxy-3-flurophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (R)-6-(4-(((R)-1-(5-ethylpyrimidin-2-yl)pyrrolidin-3-yl)methoxy-3-flurophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (S)-6-(-4-(((S)-1-(5-chloropyrimidin-2-yl)pyrrolidin-3-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (S)-6-(4-(((S)-1-(4-ethylpyrimidin-2-yl)pyrrolidine-3-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (R)-6-(4-(((S)-1-(4-ethylpyrimidin-2-yl)pyrrolidine-3-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (R)-6-(4-(((S)-1-(5-chloropyrimidin-2-yl)pyrrolidine-3-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• (S)-6-(4-(((S)-1-(5-ethylpyrimidin-2-yl)pyrrolidine-3-yl)methoxy)phenyl)-2H-benzo[d][1,3]oxathiole 3-oxide;
• or
• a pharmaceutically acceptable form thereof.