Bryostatin compounds and methods of preparing the same

A method of preparing a bryostatin compound, wherein the method comprises:

• (a) preparing a compound of formula (X) from a starting material of formula (I) or a synthon thereof or a synthetic equivalent thereof:
• wherein:
• P1 and P2 are independently a hydroxyl protecting group or synthetic equivalent thereof;
• each R and R1-R2 is independently an alkyl or a substituted alkyl;
• R12 is an alkyl or a substituted alkyl;
• and
• R11 is an acyl, a substituted acyl, an alkyl, a substituted alkyl, —CO-aryl, —CO(substituted aryl), —CO-heteroaryl, or -CO(substituted heteroaryl);
• and
• (b) preparing a compound of formula (XX) from a starting material of formula (XI) or a synthon thereof or a synthetic equivalent thereof:
• wherein:
• Z1 is an alkynyl, a substituted alkynyl, an allenyl, a substituted allenyl an alkyl or a substituted alkyl (e.g., including one or more O or N atoms in the carbon chain, or substituted with a cycloalkyl, substituted cycloalkyl, cyclic alkenyl, substituted cyclic alkenyl, aryl, substituted aryl, heteroaryl, or substituted hereoaryl);
• R12, R13 and R16 are independently an alkyl or a substituted alkyl;
• and
• P3 is H or a hydroxyl protecting group.