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US 2019/0292162 A1Published application
Thiazole derivative and applications
AssigneeEast China University of Science and Technology
InventorsHonglin LI, Yufang XU, Rui WANG, Zhenjiang ZHAO, Wenlin SONG, Liuxin XU
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Abstract
A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.
Claims11
A compound of formula I or a pharmaceutically acceptable salt or ester thereof
- Wherein,
- R1 is selected from the group consisting of H, a substituted or unsubstituted C1-C6 alkyl and C3-C6 cycloalkyl;
- R2 is selected from the group consisting of H, halogen, a substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxy, CN, NO2, hydroxyl and NRaRb;
- Ra, Rb are independently selected from H or C1-C6 alkyl;
- R3 is selected from the group consisting of H and a substituted or unsubstituted C1-C6 alkyl;
- R4 is selected from the group consisting of H and halogen;
- m is an integer from 0 to 4;
- n is an integer from 0 to 5;
- wherein, when R2 is H and R3 is H, R1 is not H.
6 more elements
-10. (canceled)
Dependencies are inferred from the claim text.