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US 2019/0292148 A1Published application
2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs and methods for their synthesis and use
AssigneeAlere San Diego, Inc.
InventorsFei HUANG, Dongpei WU, Lupe MEJORADO, Mariusz BANASZCZYK
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Abstract
The present invention relates to novel 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
Claims21
A compound or salt thereof, said compound having a general formula selected from (I), (II), (III), (IV), or (V):
- wherein R and R1 are each —CH2—R2, where R2 is a linkage chemistry which provides a terminal functional moiety selected from the group consisting of protected or unprotected sulfhydryl moieties, protected or unprotected amine moieties, primary amine-reactive moieties, sulfhydryl-reactive moieties, photoreactive moieties, carboxyl-reactive moieties, arginine-reactive moieties, and carbonyl-reactive moieties;
- X is H, N, O, C1-6 saturated alkyl straight or branched chain, C1-6 unsaturated alkyl straight or branched chain, C1-6 alkoxy, or haloalkyl;
- Y is H, C1-6 saturated alkyl straight or branched chain, C1-6 unsaturated alkyl straight or branched chain, C1-6 alkoxy, or haloalkyl;
- Z is H, C1-6 saturated alkyl straight or branched chain, C1-6 unsaturated alkyl straight or branched chain, C1-6 alkoxy, or haloalkyl.
1 more element
Dependencies are inferred from the claim text.