Novel chiral phase-transfer catalyst, and method for preparing a-amino acid by using same
AssigneeResearch Cooperation Foundation of Yeungnam University
InventorsKee Pyung NAHM, Yeon Ji LEE, Bae Geun LIM, Seung A WOO, Ji Inn OH, Won Gyoung SON
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Abstract
The present invention relates to a novel chiral phase-transfer catalyst, and a method for preparing an alpha-amino acid by using the same. According to the present invention, an alpha-amino acid of high optical purity could be synthesized in a high yield under an easy industrially applicable reaction condition by using a novel cinchona alkaloid compound as a chiral phase-transfer catalyst, and thus the present invention can be used as a key technique of the asymmetric alpha-amino acid synthesis and preparation field.
Claims15
A cinchona-alkaloid compound represented by Formula 1 below:
- wherein,
- X is selected from the group consisting of —CH2—, —C(OH)H—, —C(═O)—, —O—, —S—, —S(═O)—, and —S(O2)—;
- R is
- R1 is selected from the group consisting of hydrogen, C1 to C10 alkyl, and C1 to C5 alkoxy;
- R2 is vinyl or ethyl;
- R3 is selected from the group consisting of hydrogen, C1 to C10 alkyl, allyl, C5 to C10 aryl, naphthalen-1-yl-methyl, and anthracen-9-yl-methyl;
- and
- Y− is selected from the group consisting of:
- halogen anion of, fluoride, chloride, bromide, and iodide, IO4−, CIO4−, R4SO3−, trifluoromethane sulfonate (OTf−) and HSO4−, wherein R4 is C1-C4 alkyl or C5-C10 aryl.
Dependencies are inferred from the claim text.