Methods of determining dosing of a therapeutic agent based on measured levels of a metabolite

A device comprising a processor and a memory unit operably coupled to the processor to cause the processor to:

• receive data that comprises a dose of a therapeutic agent and a time that a subject received the dose of the therapeutic agent, wherein the therapeutic agent inhibits a metabolic pathway of the subject;
• generate a reminder that that provides a time when a next dose of the therapeutic agent should be administered to the subject, wherein the time when the next dose of the therapeutic agent should be administered is generated based on a relationship between the dose of the therapeutic agent and a threshold level of the metabolite, wherein administration of the next dose raises or maintains a level of the metabolite in the subject above the threshold level to sufficiently alter the metabolic pathway to thereby ameliorate, reduce, or eliminate at least one sign or symptom of a disorder in the subject;
• and
• output the reminder to the subject.

A method for assessing in real-time an impact on a tumor of a therapeutic agent, the method comprising:

• monitoring, in real-time, a molecule that is associated with a metabolic pathway in a tumor as the molecule moves through the metabolic pathway in the tumor;
• monitoring, in real time, an oxygenation level in a tumor;
• and
• assessing an impact on the tumor of a therapeutic agent that has been administered to a subject based on results of both of the monitoring steps.