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US 2019/0290832 A1Published application
System and method for platelet removal during mononuclear cell collection
AssigneeFenwal, Inc.
InventorsJONATHAN W. PRENDERGAST, LAN T. NGUYEN, KATHERINE N. RADWANSKI
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Abstract
A method of collecting mononuclear cells, comprising separating whole blood into cellular components and platelets suspended in plasma, separating the platelets suspended in plasma into platelet concentrate and platelet-poor plasma, combining the cellular components with the platelet-poor plasma to form a first mixture, and separating the first mixture into mononuclear cells and at least one component.
Claims21
1-15. (canceled)
A method of collecting mononuclear cells, comprising:
- separating with a separator whole blood from a whole blood source into cellular components and platelet-rich plasma;
- removing the cellular blood components and the platelet-rich plasma from the separator;
- returning the cellular components to the whole blood source without returning at least a portion of the platelets in the platelet-rich plasma to the whole blood source to reduce platelet concentration of whole blood subsequently flowing into the separator from the whole blood source;
- and
- separating lower platelet concentration whole blood from the whole blood source into mononuclear cells and at least one component.
2 more elements
A blood separation system, comprising:
- a separator including a controller;
- and
- a disposable fluid circuit configured to work in association with the separator, wherein the controller is configured to control the separator to
- separate whole blood from a whole blood source into cellular components and platelet-rich plasma,
- remove the cellular blood components and the platelet-rich plasma from the separator,
- return the cellular blood components to the whole blood source without returning at least a portion of the platelets in the platelet-rich plasma to the whole blood source to reduce platelet concentration of whole blood subsequently flowing into the separator from the whole blood source, and
- separate lower platelet concentration whole blood from the whole blood source into mononuclear cells and at least one component.
4 more elements
Dependencies are inferred from the claim text.