Wound dressing or dermal patch
AssigneeBSN Medical, Inc.
InventorsAnnahit Arshi, Karsten Hemmrich, Christian Schulze
Life of this patent
Estimating the term…
Abstract
The invention relates to a pharmaceutical composition and in particular a dermal patch or wound dressing comprising an acid-hydrolyzing oligomer and/or polymer and an acid-activated prodrug such that the active principle in the pharmaceutical composition or in the dermal patch or wound dressing is formed A from the prodrug under the effect of acid. The invention further relates to a corresponding method for releasing active principles from a pharmaceutical composition.
Claims20
1-19. (canceled)
Skin or wound patch comprising
- (a) an oligomer and/or polymer that can produce an acidic environment by its hydrolysis, and
- (b) an acid-activatable prodrug,
- whereby the acid-activatable prodrug is activatable in the skin or wound patch by the acid produced by hydrolysis.
Pharmaceutical composition for the release of a pharmaceutically active substance, comprising:
- (a) an oligomer or polymer that can produce acid by means of hydrolysis;
- and
- (b) an acid-activatable prodrug;
- (c) a radical scavenger system;
- whereby the acid-activatable prodrug is activatable by the acid produced by hydrolysis.
Method for the release of an active substance from a pharmaceutical composition and, in particular, from a skin or wound patch, comprising the following steps:
- (a) providing a pharmaceutical composition and, in particular, a skin or wound patch comprising an oligomer and/or polymer that can produce an acid environment by means of hydrolysis, and an acid-activatable prodrug;
- (b) contacting the polymer and/or oligomer to an inductor or catalyst such that the inductor or catalyst effects at least partial hydrolysis of the oligomer and/or polymer and such that an acidic environment is thus produced;
- (c) conversion of the acid-activatable prodrug into an active substance by the acidic environment from step (b);
- (d) release of the active substance from the pharmaceutical composition and, in particular, from the skin or wound patch.
Dependencies are inferred from the claim text.