Production of Re-188/186 Particles
AssigneeOncobeta International GmbH
InventorsTuomo Nikula, Thomas Wendler
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Abstract
Provided is a process of producing activated particles comprising 188Re-isotopes and/or 186Re-isotopes by irradiating non-volatile and water-insoluble starting particles comprising a rhenium compound with neutrons. Further provided is a process of producing corresponding non-volatile and water-insoluble starting particles. Further provided are respective starting particles and activated particles, respectively, and a composition comprising a plurality of activated particles. The activated particles, and the composition comprising same are suitable for use in radionuclide therapy, and for cosmetic applications.
Claims20
A process of producing activated particles comprising 188Re and/or 186Re, comprising:
- a) providing non-volatile and water-insoluble starting particles comprising a rhenium compound,
- b) irradiating the particles with neutrons, wherein at least part of the 187Re-atoms undergo a neutron capture to form 188Re and/or wherein at least part of the 185Re-atoms undergo a neutron capture to form 186Re, thereby forming said activated particles.
A process of producing non-volatile and water-insoluble starting particles comprising a rhenium compound, said particles having an average particle size of from 1 nanometer to 100 micrometers, the process comprising:
- i) providing a rhenium solution,
- ii) optionally, mixing the rhenium solution with at least one additive,
- iii) reacting the rhenium solution with a precipitating agent, thereby forming said rhenium compound,
- iv) precipitating said rhenium compound,
- v) isolating particles comprising the precipitated rhenium compound,
- vi) optionally, washing and/or filtering and/or drying said particles.
The non-volatile and water-insoluble isolated starting particle of claim 6, comprising an activated particle comprising a rhenium compound and 187Re-atoms, wherein a ratio of 188W-atoms to 188Re-atoms in said activated particle is less than 50 ppm.
The non-volatile and water-insoluble isolated starting particle of claim 6, comprising an activated particle comprising a rhenium compound and 186Re-atoms, wherein optionally at least 40% of the rhenium atoms are 185Re-atoms and 186Re-atoms.
A non-volatile and water-insoluble isolated starting particle comprising a rhenium compound, the particle having a particle size in the range of from 1 nanometer to 100 micrometers.
Dependencies are inferred from the claim text.